Metabolic
An amylin-analog peptide examined in preclinical metabolic research.
Type
Synthetic peptide (acylated, disulfide-cyclized, 37 residues)
Molecular weight
~4,409 g/mol
CAS number
1415456-99-3
Amino acids
37
Fatty acid chain
C20 diacid
Modification
N-terminal disulfide; Lys C20 fatty-diacid acylation; C-terminal amide; substitutions reduce fibrillation.
A lipidated amylin analogue acting as a non-selective agonist of the calcitonin-family class B GPCRs - the amylin receptors (AMY1-3R) and the calcitonin receptor. The C20-diacid acylation provides albumin binding.
Research Focus
Studied in amylin/calcitonin-receptor pharmacology and preclinical metabolic research.
Lyophilized
-20°C (-80°C long term)
powder typically stable ~24 months.
Reconstituted
-20°C ~1 month
2-8°C short-term; formulate at low pH to limit fibrillation.
High fibrillation propensity - avoid neutral pH on storage, avoid freeze-thaw, protect from light.
Primary research
Kruse T, et al. (2021). J Med Chem — Development and characterization of a long-acting amylin-analogue peptide (J Med Chem, 2021)
Fletcher MM, et al. (2021). J Pharmacol Exp Ther — Receptor-pharmacology study of AMY (CG) at calcitonin-family G protein-coupled receptors (J Pharmacol Exp Ther, 2021)
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
