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Type
Synthetic peptide (acylated, 31 residues)
Molecular formula
C187H291N45O59
Molecular weight
~4,114 g/mol
CAS number
910463-68-2
Amino acids
31
Fatty acid chain
C18 diacid
Sequence
H-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys[C18-diacid/γ-Glu-AEEA₂]-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-NH₂
Modification
Aib8 and Arg34 substitutions; Lys26 C18 fatty-diacid acylation via gamma-Glu and two AEEA linkers.
A 31-residue synthetic peptide incorporating Aib at position 8 and Arg at position 34, with the Lys26 side chain acylated to a C18 fatty diacid via a γ-Glu/AEEA spacer. The Aib8 substitution confers resistance to enzymatic cleavage; the C18-diacid side chain provides reversible albumin binding that extends serum half-life. It has been characterized binding the extracellular domain and transmembrane pocket of a class B G protein–coupled receptor by cryo-EM.
Lyophilized
20°C (-80°C long term)
powder typically stable ~24 months.
Avoid freeze-thaw; protect from light; keep sealed and dry. Self-associates in aqueous solution.
Reviews
Tsiampali C, Vachliotis ID, Goulas A, Polyzos SA (2024). Hormones (Athens)
Knudsen LB, Lau J (2019). Front Endocrinol
Reviews
Aroda VR, Ahmann A, Cariou B, et al. (2019). Diabetes Metab
Nauck MA, Quast DR (2021). Front Endocrinol
Shi FH, Li H, Cui M, et al. (2018). Front Pharmacol
Meier JJ (2021). Front Endocrinol
Abusedera O, Sherif J, Smida M, Fredericks S (2025). J Clin Med
Douros JD, et al. (2024). J Endocrinol
Rehman SU, Kolanu ND, Mushtaq MM, et al. (2024). Cureus
Weiskirchen R, Lonardo A (2025). Med Sci (Basel)
Clinical
Marso SP, et al. (2016). N Engl J Med
Husain M, et al. (2019). N Engl J Med
Lincoff AM, et al. (2023). N Engl J Med
Garvey WT, et al. (2022). Nat Med
Primary research
Niu S, Chen S, et al. (2022). Front Endocrinol
Zhang X, Belousoff MJ, Liang YL, et al. (2021). Cell Rep
Lau J, et al. (2015). J Med Chem
Cary BP, Deganutti G, Zhao P, et al. (2022). Nat Chem Biol
Husain M, et al. (2020). Cardiovasc Diabetol
Husain M, et al. (2022). Cardiovasc Diabetol
Strain WD, et al. (2022). Stroke
Mellbin LG, et al. (2024). Eur Heart J
Alkhouri N, Herring R, Kabler H, et al. (2022). J Hepatol
Inia JA, Stokman G, Morrison MC, et al. (2023). Int J Mol Sci
Soto-Catalán M, Opazo-Ríos L, Quiceno H, et al. (2024). Int J Mol Sci
Zhu R, Chen S (2023). Front Endocrinol
Luo Y, Yang S, Zeng H, et al. (2025). Nutr Metab (Lond)
Liu Y, et al. (2026). J Biomol Struct Dyn