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These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
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Quality & methods
Molecular Profile
Molecular Profile
Type
Synthetic linear peptide (acylated, 39 residues)
Molecular formula
C225H348N48O68
Molecular weight
~4,814 g/mol
CAS number
2023788-19-2
Amino acids
39
Fatty acid chain
C20 diacid (icosanedioyl) at Lys20
Sequence
Tyr–Aib–Glu–Gly–Thr–Phe–Thr–Ser–Asp–Tyr–Ser–Ile–Aib–Leu–Asp–Lys–Ile–Ala–Gln–Lys–Ala–Phe–Val–Gln–Trp–Leu–Ile–Ala–Gly–Gly–Pro–Ser–Ser–Gly–Ala–Pro–Pro–Pro–Ser (C-terminal amide)
Modification
Positions 2 and 13 are α-aminoisobutyric acid (Aib); Lys20 bears an Nε-conjugated γ-Glu-(AEEA)₂ linker with a C20 fatty diacid (icosanedioyl); C-terminal Ser is amidated.
Mechanism & Target Class
Mechanism & Target Class
A 39-residue synthetic peptide. Positions 2 and 13 are α-aminoisobutyric acid (Aib), conferring resistance to enzymatic degradation by DPP-4; the C20 fatty-diacid chain at Lys20 promotes reversible albumin binding, extending circulatory half-life. Cryo-EM studies have characterized how the N-terminal region engages the orthosteric site of its class B G protein–coupled receptor targets via hydrogen bonds and ionic interactions.
Storage & Handling
Storage & Handling
Lyophilized
20°C (-80°C long term)
powder typically stable ~24 months.
Aliquot to avoid freeze-thaw; protect from light; keep sealed and dry.
References
References
Reviews
- 1
Galindo RJ, Cheng AYY, Longuet C, et al. (2026). Diabetes Ther
- 2
Nauck MA, D'Alessio DA (2022). Cardiovasc Diabetol
Reviews
- 3
Sun B, Li Z, Xiao Y, et al. (2022). Nat Rev Drug Discov
- 4
Min T, et al. (2021). Diabetes Ther
- 5
Nowak M, et al. (2022). Endokrynol Pol
- 6
Forzano I, et al. (2022). Int J Mol Sci
Clinical
- 10
Jastreboff AM, Aronne LJ, Ahmad NN, et al. (2022). N Engl J Med
- 11
Frias JP, Davies MJ, Rosenstock J, et al. (2021). N Engl J Med
- 12
Frias JP, et al. (2018). Lancet
- 13
Ludvik B, et al. (2021). Lancet
Primary research
- 17
Sun B, Willard FS, Feng D, et al. (2022). Proc Natl Acad Sci U S A
- 18
Willard FS, Douros JD, Gabe MBN, et al. (2020). JCI Insight
- 19
Coskun T, et al. (2018). Mol Metab
- 20
Samms RJ, et al. (2021). J Clin Invest
Primary Database
Primary Database
Reviews
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Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.