Growth Factor
A growth-factor analog studied in cellular research models.
Type
Recombinant protein analogue (83 residues)
Molecular weight
~9,100 g/mol (~9.1 kDa)
CAS number
946870-92-4
Amino acids
83
Sequence
MFPAMPLSSLFVNGPRTLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Modification
13-residue N-terminal extension (MFPAMPLSSLFVN) plus a Glu3->Arg3 substitution; three intramolecular disulfides.
An agonist analogue of the type-1 IGF receptor (IGF-1R). The Arg3 substitution and N-terminal extension lower affinity for IGF-binding proteins while preserving IGF-1R agonist activity; downstream signaling is via the PI3K/Akt and MAPK/ERK pathways.
Research Focus
Used as a cell-culture supplement and in IGF-1R signaling research.
Lyophilized
-20°C long term
protect from moisture.
Reconstituted
2-8°C
aliquot to minimize freeze-thaw and ambient exposure.
Disulfide-bonded protein; sensitive to repeated freeze-thaw and oxidation.
Also known as: Long R3 IGF-1, Long [Arg3] IGF-1
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
