Metabolic
A GLP-1 receptor agonist studied in preclinical metabolic research.
Type
Synthetic peptide (acylated, 31 residues)
Molecular formula
C187H291N45O59
Molecular weight
~4,114 g/mol
CAS number
910463-68-2
Amino acids
31
Fatty acid chain
C18 diacid
Modification
Aib8 and Arg34 substitutions; Lys26 C18 fatty-diacid acylation via gamma-Glu and two AEEA linkers.
A GLP-1 analogue (two substitutions from human GLP-1) that binds the GLP-1 receptor, a class B GPCR. The Aib8 substitution resists DPP-4 cleavage; the C18-diacid side chain provides reversible albumin binding.
Research Focus
Used as a reference GLP-1R agonist in receptor-pharmacology and preclinical metabolic research.
Lyophilized
-20°C (-80°C long term)
powder typically stable ~24 months.
Reconstituted
-20°C ~1 month
2-8°C for short-term use only.
Avoid freeze-thaw; protect from light; keep sealed and dry. Self-associates in aqueous solution.
Lau J, et al. (2015). J Med Chem
Knudsen LB, Lau J (2019). Front Endocrinol
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
