Metabolic
A dual-receptor agonist examined in preclinical metabolic research.
Type
Synthetic peptide (acylated, 39 residues)
Molecular formula
C225H348N48O68
Molecular weight
~4,814 g/mol
CAS number
2023788-19-2
Amino acids
39
Fatty acid chain
C20 diacid
Modification
Aib at positions 2 and 13; C-terminal amide; Lys20 C20 fatty-diacid acylation via gamma-Glu and two AEEA linkers.
A GIP-sequence-based single peptide that activates two class B GPCRs - the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), with GIPR-biased potency. Aib residues confer protease resistance; the C20-diacid side chain provides albumin binding.
Research Focus
Used as a reference dual GIP/GLP-1R agonist in receptor-binding and preclinical metabolic research.
Lyophilized
-20°C (-80°C long term)
powder typically stable ~24 months.
Reconstituted
-20°C ~1 month
2-8°C for short-term use only.
Aliquot to avoid freeze-thaw; protect from light; keep sealed and dry.
Coskun T, et al. (2018). Mol Metab
Nauck MA, D'Alessio DA (2022). Cardiovasc Diabetol
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
