Metabolic
A small-molecule compound investigated in preclinical metabolic research.
5-Amino-1MQ is studied in metabolism research as a blocker of an enzyme called NNMT, which becomes overactive in fat and muscle tissue. Researchers investigate in preclinical models how NNMT inhibition relates to cellular energy metabolism, adipocyte lipid handling, and metabolic-rate endpoints.
Type
Small molecule (NNMT inhibitor)
Molecular formula
C10H11IN2 (iodide salt)
Molecular weight
286.11 g/mol (iodide salt); 159.21 g/mol (free cation)
CAS number
42464-96-0 (iodide salt)
Modification
Quaternary N-methyl quinolinium with a 5-amino substituent; commonly supplied as the iodide salt.
A substrate-site small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosyl-methionine. The cationic quinolinium ring occupies the nicotinamide pocket.
Research Focus
Studied in NNMT enzymology and preclinical metabolic research.
Lyophilized
Store solid at -20°C, desiccated and protected from light
typically stable ~24 months.
Reconstituted
DMSO or aqueous stocks at -20°C/-80°C in aliquots
protect from light.
Hygroscopic salt - keep desiccated; protect from light; avoid freeze-thaw of stocks.
Neelakantan H, et al. (2018). Biochem Pharmacol
Neelakantan H, et al. (2019). Biochem Pharmacol
Also known as: 5-amino-1-methylquinolinium
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
