Metabolic
A peptide fragment studied in preclinical metabolic research.
AOD-9604 is a synthetic peptide fragment modeled on the C-terminal region of human growth hormone. It appears in preclinical (cell and animal) lipid-metabolism research and in analytical-chemistry literature. Supplied strictly for laboratory research. Not for human or veterinary use.
Type
Synthetic peptide (cyclic, 16 residues)
Molecular formula
C78H123N23O23S2
Molecular weight
~1,815 g/mol
CAS number
221231-10-3
Amino acids
16
Sequence
YLRIVQCRSVEGSCGF
Modification
hGH(176-191) fragment with an N-terminal Tyr; intramolecular Cys7-Cys14 disulfide.
A disulfide-cyclized fragment reproducing the C-terminal region of human growth hormone; it does not bind the growth hormone receptor. Preclinical work associates its activity with the beta-3 adrenergic receptor pathway in adipose tissue.
Research Focus
Studied in preclinical adipocyte and lipid-metabolism research.
Lyophilized
-20°C
powder typically stable ~24 months desiccated.
Reconstituted
-20°C for several weeks
2-8°C short-term only.
Avoid freeze-thaw; protect from light and moisture; disulfide is oxidation-sensitive - avoid reducing agents.
Reviews
Mendias CL, Awan TM. (2026). Sports Medicine — Review of pharmacology, safety, and regulatory status of approved and unapproved peptides
Kopchick JJ, et al. (2020). Nat Rev Endocrinol — Review of growth-hormone effects on adipose tissue
Primary research
Cox HD, et al. (2015). Drug Test Anal — Detection and in-vitro metabolism analysis
Kwon DR, Park GY. (2015). Ann Clin Lab Sci — Intra-articular study in a knee-osteoarthritis model (rabbit)
Orlovius AK, et al. (2013). Drug Test Anal — Immunoassay-interference analysis
Heffernan M, et al. (2001). Endocrinology — Lipid-metabolism study in obese and beta3-AR knockout mice
Heffernan MA, et al. (2001). Int J Obes — Fat-oxidation study in obese mice
Ng FM, et al. (2000). Horm Res — Metabolic study of the synthetic lipolytic domain in Zucker rats
Ng FM, et al. (2000). J Mol Endocrinol — Molecular and cellular lipid-metabolism study of a precursor analog
Ogru E, et al. (2000). J Pept Res — Conformational and biological analysis
Wu Z, Ng FM. (1993). Biochem Mol Biol Int — Foundational antilipogenic-activity study of the hGH C-terminal fragment
Also known as: Tyr-hGH 176-191
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
