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For Research Purposes Only
Out of StockAOD-9604
Third-Party TestedPurity Standards
Total
$34.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Synthetic peptide (cyclic, 16 residues)
Molecular formula
C78H123N23O23S2
Molecular weight
~1,815 g/mol
CAS number
221231-10-3
Amino acids
16
Sequence
YLRIVQCRSVEGSCGF
Modification
N-terminal tyrosine extension of the hGH 177–191 sequence; intramolecular Cys7–Cys14 disulfide bond forming a cyclic loop.
Mechanism & Target Class
Mechanism & Target Class
A disulfide-cyclized 16-residue peptide corresponding to the C-terminal domain of human growth hormone (residues 177–191 plus an N-terminal tyrosine). The N-terminal tyrosine extension and the intramolecular Cys7–Cys14 disulfide bond constrain the backbone into a cyclic loop; NMR conformational analysis of the solution structure identifies type I β-turns in this region. The cyclic loop is distinct from the N-terminal region of the full-length protein, and the tyrosine modification was introduced to improve stability relative to the unmodified C-terminal fragment.
Storage & Handling
Storage & Handling
Lyophilized
20 °C or colder, protected from light and moisture
stable for extended periods when kept frozen and sealed.
Avoid repeated freeze–thaw cycles; protect from light and moisture; the disulfide is oxidation-sensitive — avoid reducing agents. The N-terminal tyrosine modification was introduced to improve stability relative to the unmodified C-terminal fragment.
References
References
Reviews
- 1
Mendias CL, Awan TM. (2026). Sports Medicine
- 2
Kopchick JJ, et al. (2020). Nat Rev Endocrinol
Reviews
- 3
Moré MI, Kenley D. (2014). Journal of Endocrinology and Metabolism
- 4
Stier H, Vos E, Kenley D. (2013). Journal of Endocrinology and Metabolism
- 5
Liao HJ, et al. (2024). Cartilage
- 6
Vijayakumar A, et al. (2010). Growth Horm IGF Res
Primary research
- 7
Cox HD, et al. (2015). Drug Test Anal
- 8
Kwon DR, Park GY. (2015). Ann Clin Lab Sci
- 9
Vanhee C, et al. (2014). Drug Test Anal
- 10
Orlovius AK, et al. (2013). Drug Test Anal
- 11
Heffernan M, et al. (2001). Endocrinology
- 12
Heffernan MA, et al. (2001). Int J Obes
- 13
Heffernan MA, et al. (2000). Am J Physiol Endocrinol Metab
- 14
Ng FM, et al. (2000). Horm Res
- 15
Ng FM, et al. (2000). J Mol Endocrinol
- 16
Ogru E, et al. (2000). J Pept Res
- 17
Wijaya E, Ng FM. (1993). Biochem Mol Biol Int
- 18
Wu Z, Ng FM. (1993). Biochem Mol Biol Int
- 19
Ng FM, Bornstein J. (1978). American Journal of Physiology
- 20
Zhao L, Jiang H. (2023). Front Endocrinol
- 21
Høyer KL, et al. (2020). Physiol Rep
Primary Database
Primary Database
Also known as: hGH Fragment 176-191, Tyr-hGH 177-191
View this compound in the Research Library →Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
