Secretagogue
A growth-hormone-releasing analog examined in preclinical secretagogue research.
Type
Synthetic peptide (GRF analogue)
Molecular formula
C165H269N47O46
Molecular weight
~3,647 g/mol
CAS number
446262-90-4 (with DAC); 863288-34-0 (no-DAC)
Amino acids
29
Modification
Tetrasubstituted GRF(1-29) with a C-terminal Lys-linked maleimidopropionyl albumin-binding group (DAC); C-terminal amide.
A synthetic analogue of growth-hormone-releasing hormone (GRF 1-29) that binds the GHRH receptor (GHRHR), a class B GPCR on pituitary somatotrophs. The DAC group enables reversible covalent binding to serum albumin. A no-DAC variant (Mod GRF 1-29; ~3,368 g/mol; PubChem CID 91976842) is also offered.
Research Focus
Studied in GHRH-receptor pharmacology and growth-hormone / IGF-1 axis research.
Lyophilized
-20°C
typically stable 24-36 months desiccated and protected from light.
Reconstituted
2-8°C for short-term use
-20°C/-80°C for longer storage.
Avoid freeze-thaw; aliquot; protect from light and moisture. The DAC maleimide group is thiol-reactive.
Clinical
Teichman SL, et al. (2006). J Clin Endocrinol Metab — GH/IGF-1 stimulation study in healthy adults (DAC variant)
Ionescu M, Frohman LA. (2006). J Clin Endocrinol Metab — GH pulsatility under continuous stimulation (DAC variant)
Primary research
Timms M, et al. (2019). Drug Test Anal — LC-MS/MS confirmation in equine plasma (DAC variant)
Timms M, et al. (2019). Drug Test Anal — Immuno-PCR screen in equine plasma (DAC variant)
Henninge J, et al. (2010). Drug Test Anal — Identification in an unknown preparation (DAC variant)
Sackmann-Sala L, et al. (2009). Growth Horm IGF Res — Serum-proteome-changes study (DAC variant)
Alba M, et al. (2006). Am J Physiol Endocrinol Metab — GHRH-knockout mouse model (DAC variant)
Jetté L, et al. (2005). Endocrinology — Lead-identification study (in vitro + rat PK; DAC variant)
Also known as: CJC-1295 with DAC, DAC:GRF, Mod GRF 1-29 (no-DAC variant)
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
