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Circadian
An amphiphilic synthetic nonapeptide with no identified gene precursor or cloned receptor.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Type
Synthetic peptide (nonapeptide)
Molecular formula
C35H48N10O15
Molecular weight
848.8 g/mol
CAS number
62568-57-4
Amino acids
9
Sequence
WAGGDASGE
Modification
None (native peptide)
An amphiphilic nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, ~850 Da) whose gene precursor has not been identified and for which no dedicated receptor has been cloned. It has no close sequence homologues and co-localizes immunohistochemically with other small peptides in structural distribution-mapping studies. The unmodified backbone is subject to rapid degradation by aminopeptidases, giving a short in-vitro half-life that is relevant to handling and assay design; alpha-Asp/beta-Asp isomerization at the Asp residues is a recognized identity consideration.
Lyophilized
20 °C
protect from light and moisture; stable up to 1 year.
Sensitive to aminopeptidase cleavage; alpha-Asp/beta-Asp isomerization is relevant to identity; protect from light.
Reviews
Gimble JM, et al. (2009). Obes. Rev.
Kovalzon VM, Strekalova TV (2006). J. Neurochem.
Graf MV, Kastin AJ (1986). Peptides
Clinical
Westrin A, Ekman R, Träskman-Bendz L (1998). Biol. Psychiatry
Bes F, Hofman W, Schuur J, van Boxtel C (1992). Neuropsychobiology
Schneider-Helmert D (1986). Eur. Neurol.
Schneider-Helmert D, Schoenenberger GA (1981). Experientia
Dick P, Grandjean ME, Tissot R (1983). Neuropsychobiology
Dick P, et al. (1984). Eur. Neurol.
Lindström LH, Ekman R, Walleus H, Widerlöv E (1985). Prog. Neuropsychopharmacol. Biol. Psychiatry
Ernst A, et al. (1987). J. Neurol.
Primary research
Sudakova KV, et al. (2004). Pathophysiology
Charnay Y, et al. (1989). Neuroendocrinology
Iyer KS, et al. (1988). Proc. Natl. Acad. Sci. USA
Graf MV, Schoenenberger GA (1987). J. Neurochem.
Graf MV, Kastin AJ, Coy DH, Fischman AJ (1985). Neuroendocrinology
Graf MV, et al. (1984). J. Clin. Endocrinol. Metab.
Monnier M, et al. (1977). Experientia
Schoenenberger GA, Monnier M (1977). Proc Natl Acad Sci USA
Marks N, Stern F, Kastin AJ, Coy DH (1977). Brain Res Bull
Khvatova EM, Rubanova NA, Prudchenko IA, Mikhaleva II (1995). FEBS Lett.
Shustanova TA, et al. (2001). Biochemistry (Mosc)
Also known as: Delta Sleep-Inducing Peptide
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
Quality & methods