GH Secretagogue
A selective secretagogue peptide studied in preclinical research.
Ipamorelin is studied for how the body releases its own growth hormone. It is a small, highly selective peptide that activates the ghrelin receptor on the pituitary gland, and it is used as a selective probe in preclinical growth-hormone-secretion research.
Type
Synthetic peptide (pentapeptide)
Molecular formula
C38H49N9O5
Molecular weight
711.9 g/mol
CAS number
170851-70-4
Amino acids
5
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2
Modification
N-terminal Aib; D-2-naphthylalanine; D-Phe; C-terminal amide.
A synthetic pentapeptide that binds the growth-hormone secretagogue receptor (GHS-R1a / ghrelin receptor), a class A GPCR on pituitary somatotrophs. It does not bind the GHRH receptor.
Research Focus
Studied in GHS-R1a receptor pharmacology and growth-hormone-secretion research.
Lyophilized
-20°C
typically stable 24-36 months desiccated and protected from light.
Reconstituted
2-8°C for short-term use
-20°C/-80°C for longer storage.
Avoid freeze-thaw; aliquot; protect from light and moisture.
Clinical
Beck DE, et al. (2014). Int J Colorectal Dis — Phase 2 trial in postoperative ileus (bowel-resection patients)
Gobburu JVS, et al. (1999). Pharm Res — PK/PD modeling study in healthy volunteers
Primary research
Greenwood-Van Meerveld B, et al. (2012). J Exp Pharmacol — Rodent postoperative-ileus model
Venkova K, et al. (2009). J Pharmacol Exp Ther — Rodent postoperative-ileus model
Adeghate E, Ponery AS. (2004). Neuro Endocrinol Lett — Pancreatic insulin-release mechanism study (rat tissue)
Jiménez-Reina L, et al. (2002). Histol Histopathol — Somatotroph-responsiveness study (young female rats)
Svensson J, et al. (2000). J Endocrinol — Bone-mineral-endpoint study (adult female rats)
Malmlöf K, et al. (2000). Growth Horm IGF Res — GH-release study under glucocorticoid conditions (rats)
Johansen PB, et al. (1999). Growth Horm IGF Res — Longitudinal bone-growth study (rats)
Raun K, et al. (1998). Eur J Endocrinol — Foundational secretagogue-characterization study
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
