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Peptide Analogs
A synthetic small-molecule acylhydrazone studied as a chemical probe in nuclear-receptor and mitochondrial-metabolism research.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Type
Synthetic small molecule (acylhydrazone / benzohydrazide chemotype)
Molecular formula
C18H14N2O2
Molecular weight
290.3 g/mol
CAS number
303760-60-3
SLU-PP-332 is a synthetic small molecule (acylhydrazone chemotype) that binds within the ligand-binding domain of the estrogen-related receptors (ERRα, ERRβ, ERRγ), a subfamily of orphan nuclear receptors within the nuclear-receptor superfamily. Despite the name, ERRs do not bind estrogen; they are constitutively active transcription factors that associate with PGC-1α/β coactivators. SLU-PP-332 was engineered from GSK4716 by medicinal-chemistry modification, and structural studies describe how it binds within the ERR ligand-binding domain and stabilizes the receptor conformation that recruits the PGC-1 coactivator.
Lyophilized
Solid form is commonly stored desiccated and protected from light
vendor practice frequently specifies −20 °C for long-term stability.
Protect from light, moisture, and heat. Discard solutions showing discoloration or precipitation. Consult the specific certificate of analysis for any given lot.
Reviews
Sopariwala DH, Nguyen H, Narkar VA (2023). International Journal of Sports Medicine
Fan W, Atkins AR, Yu RT, Downes M, Evans RM (2013). Journal of Molecular Endocrinology
Giguère V (2008). Endocr Rev
Reviews
Giguère V (2002). Trends Endocrinol Metab
Clinical
Bonanni R, Falvino A, Matticari A, Rinaldi AM, D'Arcangelo G, Cifelli P, Iundusi R, Gasbarra E, Tancredi V, Cariati I, Tarantino U (2025). Frontiers in Physiology
Primary research
Avliyakulov NK, Sobolevsky T, Ahrens E (2026). Drug Testing and Analysis
Möller T, Krug O, Thevis M (2026). Rapid Communications in Mass Spectrometry
Okda HE, Zhao P, Hayes M, Duvall C, Quillin E, Fang H, Mohammed BM, Hegazy L, Burris TP, Elgendy B (2026). International Journal of Biological Macromolecules
Billon C, Appourchaux K, Côté I, Burris TP (2025). Journal of Pharmacology and Experimental Therapeutics
Fan W, Oh TG, Wang HJ, et al. (2025). Proceedings of the National Academy of Sciences USA
Losby M, Hayes M, Valfort A, Walker J, Xu W, Zhang L, Billon C, Burris TP (2024). Molecular Pharmacology
Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP (2024). Journal of Pharmacology and Experimental Therapeutics
Xu W, Billon C, Li H, et al. (2024). Circulation
Wang XX, Myakala K, Libby AB, et al. (2023). The American Journal of Pathology
Hampton CS, Sitaula S, Billon C, et al. (2023). European Journal of Medicinal Chemistry
Billon C, Sitaula S, Banerjee S, et al. (2023). ACS Chemical Biology
Wattez JS, Eury E, Hazen BC, et al. (2023). Molecular Metabolism
Shahien M, Elagawany M, Sitaula S, et al. (2020). Bioorganic Chemistry
Huss JM, Imahashi K, Dufour CR, et al. (2007). Cell Metab
Huss JM, Torra IP, Staels B, Giguère V, Kelly DP (2004). Mol Cell Biol
Wende AR, Huss JM, Schaeffer PJ, Giguère V, Kelly DP (2005). Mol Cell Biol
Also known as: SR9861
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
| Compound | Type | Molecular weight | CAS number |
|---|---|---|---|
| SLU-PP-332This page | Synthetic small molecule (acylhydrazone / benzohydrazide chemotype) | 290.3 g/mol | 303760-60-3 |
| LUV RT | Synthetic peptide (acylated, 39 residues) | ~4,731 Da | 2381089-83-2 |
| LUV SM | Synthetic peptide (acylated, 31 residues) | ~4,114 g/mol | 910463-68-2 |
| LUV TRZ2 | Synthetic linear peptide (acylated, 39 residues) | ~4,814 g/mol | 2023788-19-2 |
| AOD-9604 | Synthetic peptide (cyclic, 16 residues) | ~1,815 g/mol | 221231-10-3 |
Comparison of laboratory reference specifications only. For research use only; not a therapeutic comparison.
Quality & methods