Dermal
A melanocortin-pathway peptide studied in preclinical research.
Melanotan II is studied for how the body produces skin pigment (melanin). It is a lab-made analogue of the natural alpha-MSH hormone and switches on the melanocortin receptors that drive pigment production, which is why it appears in preclinical research on pigmentation and melanocortin signaling.
Type
Synthetic peptide (cyclic heptapeptide)
Molecular formula
C50H69N15O9
Molecular weight
1,024.18 g/mol
CAS number
121062-08-6
Amino acids
7
Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Modification
N-terminal acetylation; C-terminal amide; cyclic lactam; contains norleucine and D-Phe.
A cyclic lactam heptapeptide analogue of alpha-MSH and a non-selective melanocortin-receptor agonist (MC1R, MC3R, MC4R, MC5R). The C-terminal amide distinguishes it from the carboxyl-terminated PT-141.
Research Focus
Studied in melanocortin-receptor pharmacology and melanogenesis/pigmentation research models.
Lyophilized
-20°C, protected from light and moisture
stable months to years.
Reconstituted
2-8°C, days to weeks
-20°C for longer aliquots.
Avoid freeze-thaw; protect from light; the cyclic structure aids metabolic stability.
Hadley ME, Dorr RT (2006). Peptides
Also known as: MT-II, MT2
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
