Research updates from Luvaminos
Subscribe for catalog updates, new research compounds, and quality documentation releases.
For researchers and labs. No spam — unsubscribe anytime.
For Research Purposes Only
Out of StockMolecular Profile
Molecular Profile
Type
Synthetic cyclic heptapeptide (cyclic lactam)
Molecular formula
C50H69N15O9
Molecular weight
1,024.18 g/mol
CAS number
121062-08-6
Amino acids
7
Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Modification
N-terminal acetylation; C-terminal amide; cyclic lactam bridge between the Asp side-chain γ-carboxyl and the Lys side-chain ε-amino group; contains norleucine (Nle) in place of methionine and D-phenylalanine in place of L-phenylalanine.
Mechanism & Target Class
Mechanism & Target Class
Melanotan II is a conformationally constrained cyclic lactam heptapeptide. It retains the conserved His-Phe-Arg-Trp core motif, with three engineered modifications relative to the parent linear sequence: substitution of methionine by norleucine, inversion of L-phenylalanine to D-phenylalanine, and a side-chain-to-side-chain lactam bridge (Asp–Lys) that locks the backbone into a defined turn conformation. These changes are associated with reduced susceptibility to enzymatic cleavage in vitro and constrain the bioactive conformation. The constrained scaffold is widely used as a reference ligand for characterizing the binding and selectivity profile of class A (rhodopsin-like) G-protein-coupled receptors in radioligand and structural-biology studies.
Storage & Handling
Storage & Handling
Lyophilized
20°C or colder for long-term storage
protected from light and moisture in a desiccated environment.
Avoid repeated freeze-thaw cycles; aliquot before freezing. Water-soluble; handle as a research-use-only laboratory reagent following standard peptide-handling practice.
References
References
Reviews
- 1
Habbema L, Halk AB, Neumann M, Bergman W (2017). International Journal of Dermatology
- 2
King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H (2007). Current Topics in Medicinal Chemistry
Reviews
- 3
Hadley ME, Dorr RT (2006). Peptides
- 4
Fung S, Hruby VJ (2005). Current Opinion in Chemical Biology
- 5
Adan RA, Gispen WH (1997). Peptides
- 6
Rouzaud F, Kadekaro AL, Abdel-Malek ZA, Hearing VJ (2005). Mutat Res
- 7
Hadley ME (2005). Peptides
- 8
Böhm M, Robert C, Malhotra S, Clément K, Farooqi S (2025). J Eur Acad Dermatol Venereol
Clinical
- 9
Wessells H, Gralnek D, Dorr R, Hruby VJ, Hadley ME, Levine N (2000). Urology
- 10
Wessells H, Levine N, Hadley ME, et al. (2000). Int J Impot Res
Primary research
- 11
Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, et al. (2021). Cell Research
- 12
Yu J, Gimenez LE, Hernandez CC, Cone RD, Stevens RC, et al. (2020). Science
- 13
Martin C, Gimenez LE, Williams SY, Cone RD, Stevens RC, Ballet S, et al. (2020). Journal of Medicinal Chemistry
- 14
Nelson ME, Bryant SM, Aks SE (2012). Clinical Toxicology
- 15
Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ (2007). Peptides
- 16
Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD (1995). Journal of Medicinal Chemistry
- 17
Al-Obeidi F, Castrucci AM, Hadley ME, Hruby VJ (1989). Journal of Medicinal Chemistry
- 18
Al-Obeidi F, Hadley ME, Pettitt BM, Hruby VJ (1989). Journal of the American Chemical Society
- 19
Hruby VJ, Wilkes BC, Hadley ME, Al-Obeidi F, Sawyer TK, et al. (1987). Journal of Medicinal Chemistry
- 20
Van der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, et al. (2002). Proc Natl Acad Sci U S A
- 21
Vemulapalli R, Kurowski S, Salisbury B, Parker E, Davis H (2001). Br J Pharmacol
- 22
Eliason NL, Martin L, Low MJ, Sharpe AL (2022). Neuropeptides
Primary Database
Primary Database
Also known as: MT-II, MT2
View this compound in the Research Library →- Jun 26, 2026Walter E.Verified
qr worked, coa matched the lot, packaging was good, order arrived quick
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
