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Type
Synthetic peptide (acylated, 44 residues)
Molecular formula
C221H366N72O67S
Molecular weight
~5,136 g/mol
CAS number
218949-48-5
Amino acids
44
Modification
Full GHRH(1-44) with an N-terminal trans-3-hexenoyl group; C-terminal amide.
A stabilized analogue of human GHRH(1-44) that binds the GHRH receptor (GHRHR), a class B GPCR. The N-terminal trans-3-hexenoyl group distinguishes it from native GHRH.
Lyophilized
20°C (-80°C extended)
typically stable 24-36 months desiccated.
Avoid freeze-thaw; aliquot; protect from light and moisture. Contains an oxidation-sensitive methionine.
Reviews
Spooner LM. (2012). Ann Pharmacother
Dhillon S. (2011). Drugs
Reviews
Tomlinson B, Hu M. (2006). Expert Opin Investig Drugs
Bedimo R. (2011). HIV AIDS (Auckl)
Clinical
Ellis RJ, et al. (2025). J Infect Dis
Russo SC, et al. (2024). AIDS
Fourman LT, et al. (2020). JCI Insight
Stanley TL, et al. (2019). Lancet HIV
Clemmons DR, et al. (2017). PLOS ONE
Stanley TL, et al. (2014). JAMA
Friedman SD, et al. (2013). JAMA Neurol
Baker LD, et al. (2012). Arch Neurol
Makimura H, et al. (2012). J Clin Endocrinol Metab
Stanley TL, et al. (2012). Clin Infect Dis
Falutz J, et al. (2010). J Clin Endocrinol Metab
Falutz J, et al. (2010). J Acquir Immune Defic Syndr
Falutz J, et al. (2008). AIDS
Falutz J, et al. (2007). NEJM
Falutz J, et al. (2005). AIDS
Primary research
Stanley TL, et al. (2011). J Clin Endocrinol Metab
González-Sales M, et al. (2015). Clin Pharmacokinet
González-Sales M, et al. (2015). J Pharmacokinet Pharmacodyn