Research updates from Luvaminos
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Peptide Analogs
A combined metabolic-research preparation pairing a mitochondrial-derived peptide with a small-molecule NNMT inhibitor.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Peptide / small-molecule blend
Molecular formula
C101H152N28O22S2
Molecular weight
~2,175 g/mol
CAS number
1627580-64-6
Sequence
MRWQEMGYIFYPRKLR
Molecular formula
C10H11IN2
Molecular weight
286.11 g/mol
CAS number
42464-96-0
Combines a mitochondrial-derived peptide (MOTS-c) with a small-molecule enzyme inhibitor (5-Amino-1MQ) that act on separate metabolic pathways; no single target applies. MOTS-c is a short cationic peptide encoded by an open reading frame within mitochondrial 12S rRNA (MT-RNR1 locus); mechanistic studies link it to inhibition of the folate-methionine one-carbon cycle, AICAR accumulation, and AMP-activated protein kinase (AMPK) activation, with stress-responsive nuclear translocation. 5-Amino-1MQ is a substrate-site small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT; EC 2.1.1.1), the cytosolic enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, yielding 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine; the cationic quinolinium ring occupies the nicotinamide substrate-binding pocket.
Lyophilized
20°C
components typically stable ~24 months desiccated and protected from light.
Avoid freeze-thaw; aliquot; protect from light and moisture. The peptide component carries oxidation-sensitive methionine residues; the small-molecule salt is hygroscopic — keep desiccated.
Reviews
Wan W, et al. (2023). J Transl Med
Yoon TK, et al. (2022). Diabetes Metab J
Miller B, et al. (2022). J Clin Invest
Reviews
Frontiers in Pharmacology (2024 review) (2024). Frontiers in Pharmacology
Roberti A, Fernández AF, Fraga MF. (2021). Mol Metab
Pissios P. (2017). Trends in Endocrinology & Metabolism
Clinical
Reynolds JC, et al. (2021). Sci Rep
Qin Q, et al. (2018). Int J Cardiol
Primary research
Kim SJ, et al. (2024). iScience
Kumagai H, et al. (2021). Am J Physiol Endocrinol Metab
Reynolds JC, et al. (2021). Nat Commun
D'Souza RF, et al. (2020). Aging (Albany NY)
Lu H, et al. (2019). J Mol Med
Kim KH, et al. (2018). Cell Metabolism
Lee C, et al. (2015). Cell Metabolism
Babula JJ, Bui D, Stevenson HL, Watowich SJ, Neelakantan H. (2024). Diabetes, Obesity and Metabolism
Dimet-Wiley AL, et al. (2024). Scientific Reports
Awosemo O, Neelakantan H, Watowich S, Ma J, Wu L, Chow DS, Liang D. (2021). Journal of Pharmaceutical and Biomedical Analysis
Sampson CM, Dimet AL, Neelakantan H, Ogunseye KO, Stevenson HL, Hommel JD, Watowich SJ. (2021). Scientific Reports
Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HYL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ. (2019). Biochemical Pharmacology
Neelakantan H, et al. (2018). Biochemical Pharmacology
Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. (2017). Journal of Medicinal Chemistry
Kraus D, Yang Q, Kong D, et al. (2014). Nature
Also known as: MOTS-c + 5-amino-1-methylquinolinium blend
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
| Compound | Type | Molecular weight | CAS number |
|---|---|---|---|
| MOTS-c / 5-Amino-1MQThis page | Peptide / small-molecule blend | — | — |
| LUV RT | Synthetic peptide (acylated, 39 residues) | ~4,731 Da | 2381089-83-2 |
| LUV SM | Synthetic peptide (acylated, 31 residues) | ~4,114 g/mol | 910463-68-2 |
| LUV TRZ2 | Synthetic linear peptide (acylated, 39 residues) | ~4,814 g/mol | 2023788-19-2 |
| AOD-9604 | Synthetic peptide (cyclic, 16 residues) | ~1,815 g/mol | 221231-10-3 |
Comparison of laboratory reference specifications only. For research use only; not a therapeutic comparison.
Quality & methods