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Out of StockMOTS-c / 5-Amino-1MQ
Third-Party TestedPurity Standards
Total
$89.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Peptide / small-molecule blend
MOTS-c
Molecular formula
C101H152N28O22S2
Molecular weight
~2,175 g/mol
CAS number
1627580-64-6
Sequence
MRWQEMGYIFYPRKLR
5-Amino-1MQ
Molecular formula
C10H11IN2
Molecular weight
286.11 g/mol
CAS number
42464-96-0
Mechanism & Target Class
Mechanism & Target Class
Combines a mitochondrial-derived peptide (MOTS-c) with a small-molecule enzyme inhibitor (5-Amino-1MQ) that act on separate metabolic pathways; no single target applies. MOTS-c is a short cationic peptide encoded by an open reading frame within mitochondrial 12S rRNA (MT-RNR1 locus); mechanistic studies link it to inhibition of the folate-methionine one-carbon cycle, AICAR accumulation, and AMP-activated protein kinase (AMPK) activation, with stress-responsive nuclear translocation. 5-Amino-1MQ is a substrate-site small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT; EC 2.1.1.1), the cytosolic enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, yielding 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine; the cationic quinolinium ring occupies the nicotinamide substrate-binding pocket.
Storage & Handling
Storage & Handling
Lyophilized
20°C
components typically stable ~24 months desiccated and protected from light.
Avoid freeze-thaw; aliquot; protect from light and moisture. The peptide component carries oxidation-sensitive methionine residues; the small-molecule salt is hygroscopic — keep desiccated.
References
References
Reviews
- 1
Wan W, et al. (2023). J Transl Med
- 2
Yoon TK, et al. (2022). Diabetes Metab J
Reviews
- 3
Miller B, et al. (2022). J Clin Invest
- 4
Frontiers in Pharmacology (2024 review) (2024). Frontiers in Pharmacology
- 5
Roberti A, Fernández AF, Fraga MF. (2021). Mol Metab
- 6
Pissios P. (2017). Trends in Endocrinology & Metabolism
Clinical
- 7
Reynolds JC, et al. (2021). Sci Rep
- 8
Qin Q, et al. (2018). Int J Cardiol
Primary research
- 9
Kim SJ, et al. (2024). iScience
- 10
Kumagai H, et al. (2021). Am J Physiol Endocrinol Metab
- 11
Reynolds JC, et al. (2021). Nat Commun
- 12
D'Souza RF, et al. (2020). Aging (Albany NY)
- 13
Lu H, et al. (2019). J Mol Med
- 14
Kim KH, et al. (2018). Cell Metabolism
- 15
Lee C, et al. (2015). Cell Metabolism
- 16
Babula JJ, Bui D, Stevenson HL, Watowich SJ, Neelakantan H. (2024). Diabetes, Obesity and Metabolism
- 17
Dimet-Wiley AL, et al. (2024). Scientific Reports
- 18
Awosemo O, Neelakantan H, Watowich S, Ma J, Wu L, Chow DS, Liang D. (2021). Journal of Pharmaceutical and Biomedical Analysis
- 19
Sampson CM, Dimet AL, Neelakantan H, Ogunseye KO, Stevenson HL, Hommel JD, Watowich SJ. (2021). Scientific Reports
- 20
Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HYL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ. (2019). Biochemical Pharmacology
- 21
Neelakantan H, et al. (2018). Biochemical Pharmacology
- 22
Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. (2017). Journal of Medicinal Chemistry
- 23
Kraus D, Yang Q, Kong D, et al. (2014). Nature
Also known as: MOTS-c + 5-amino-1-methylquinolinium blend
View this compound in the Research Library →Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
