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Dermal
An acetylated octapeptide investigated as a SNARE-complex / SNAP-25 mimetic in cosmetic-science and neuroexocytosis mechanistic research.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Type
Synthetic octapeptide (8 amino acids)
Molecular formula
C42H72N16O15S
Molecular weight
1073.2 g/mol
CAS number
868844-74-0
Amino acids
8
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Modification
N-terminal acetylation and C-terminal amidation (reduces amino- and carboxypeptidase susceptibility); two-residue Ala-Asp extension of the parent six-residue Acetyl Hexapeptide-8 scaffold.
SNAP-8 is designed to mimic the N-terminal region of SNAP-25, a component of the ternary SNARE complex (SNAP-25 / syntaxin / VAMP-synaptobrevin) that drives Ca²⁺-dependent synaptic vesicle fusion and neurotransmitter exocytosis. By competing with native SNAP-25 for incorporation into SNARE complex formation, the peptide is proposed to modulate vesicle docking and neurotransmitter release — a mechanism of competitive interference at the protein-assembly level, distinct from proteolytic cleavage mechanisms. The two-residue extension over the parent hexapeptide covers a larger portion of the SNAP-25 N-terminal helical segment, which structural studies identify as critical for SNARE complex assembly. Computational work additionally implicates synaptotagmin-1 (the Ca²⁺ sensor for exocytosis) as a potential secondary interaction site for this peptide class.
Lyophilized
20°C, sealed, protected from light and moisture
~24 months.
Methionine residue is oxidation-sensitive — protect from light and oxygen; avoid freeze-thaw cycles; keep sealed.
Reviews
Khvotchev M, Soloviev M. (2022). Biomolecules
Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. (2020). Frontiers in Chemistry
Jahn R, Fasshauer D. (2012). Nature
Reviews
Zdrada-Nowak J, Surgiel-Gemza A, Szatkowska M. (2025). Int J Mol Sci
Pintea A, Manea A, Pintea C, Vlad RA, Bîrsan M, Antonoaea P, Rédai EM, Ciurba A. (2025). Biomolecules
Rizo J, Xu J. (2015). Annu Rev Biophys
Clinical
Shin et al. (2024). Annals of Dermatology
Xing M, Liu H, Meng F, Ma Y, Zhang S, Gao Y. (2022). Polymers (Basel)
Avcil M, Akman G, Klokkers J, Jeong D, Çelik A. (2020). Journal of Cosmetic Dermatology
Primary research
Baglamis S, Feyzioglu-Demir E, Akgol S. (2023). Polymer Bulletin
Ji M, et al. (2020). Journal of Analytical Science and Technology
Wongrattanakamon P, Nimmanpipug P, Sirithunyalug B, Jiranusornkul S. (2018). Molecular and Cellular Biochemistry
Lim SH, Sun Y, Thiruvallur Madanagopal T, Rosa V, Kang L. (2018). Scientific Reports
Blanes-Mira C, Merino JM, Valera E, Fernandez-Ballester G, Gutierrez LM, Viniegra S, Perez-Paya E, Ferrer-Montiel A. (2004). Journal of Neurochemistry
Blanes-Mira C, et al. (2002). Int J Cosmet Sci
Apland JP, Biser JA, Adler M, Ferrer-Montiel AV, Montal M, Canaves JM, Filbert MG. (1999). Journal of Applied Toxicology
Ferrer-Montiel AV, Gutierrez LM, Apland JP, Canaves JM, Gil A, Viniegra S, Biser JA, Adler M, Montal M. (1998). FEBS Letters
Gutierrez LM, Viniegra S, Rueda J, Ferrer-Montiel AV, Canaves JM, Montal M. (1997). Journal of Biological Chemistry
Gutierrez LM, Canaves JM, Ferrer-Montiel AV, Reig JA, Montal M, Viniegra S. (1995). FEBS Letters
Blanes-Mira C, Pastor MT, Valera E, Fernández-Ballester G, Merino JM, Gutierrez LM, Perez-Payá E, Ferrer-Montiel A. (2003). Biochemical Journal
Ramakrishnan S, Bera M, Coleman J, Rothman JE, Krishnakumar SS. (2020). eLife
Pozzi D, Corradini I, Matteoli M. (2019). Neuroscience
Also known as: Acetyl Octapeptide-3, Acetyl Glutamyl Heptapeptide-1, Ac-EEMQRRAD-NH2
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
| Compound | Type | Molecular weight | CAS number |
|---|---|---|---|
| SNAP-8This page | Synthetic octapeptide (8 amino acids) | 1073.2 g/mol | 868844-74-0 |
| GHK-Cu | Tripeptide copper(II) complex | ~403.9 g/mol (free GHK ligand 340.4 g/mol) | 89030-95-5 |
| BPC-157 + TB-500 + GHK-Cu | Peptide blend | — | — |
| Melanotan I | Synthetic peptide (linear tridecapeptide) | ~1,646.9 g/mol | 75921-69-6 |
| AHK-Cu | Synthetic copper(II)–tripeptide coordination complex | ~416.9 g/mol (AHK-Cu complex); free AHK tripeptide 354.40 g/mol | 682809-81-0 |
Comparison of laboratory reference specifications only. For research use only; not a therapeutic comparison.
Quality & methods