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Dermal
A copper-binding tripeptide investigated in dermal and cellular research.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Type
Tripeptide copper(II) complex
Molecular formula
C14H24CuN6O4
Molecular weight
~403.9 g/mol (free GHK ligand 340.4 g/mol)
CAS number
89030-95-5
Amino acids
3
Sequence
Gly-His-Lys + Cu(II)
Modification
Copper(II) complex of Gly-His-Lys; Cu coordinated by the N-terminal amine, backbone amide nitrogen and histidine imidazole.
The copper(II) coordination complex of the tripeptide glycyl-L-histidyl-L-lysine, functioning structurally as a high-affinity copper carrier. Research characterizes its interactions with extracellular-matrix and copper-dependent pathways.
Lyophilized
20°C, sealed and protected from light/moisture
stable months to years.
A blue/violet color indicates intact copper coordination; avoid freeze-thaw; aqueous stability is pH-dependent.
Reviews
Mortazavi SM, et al. (2024). BioImpacts
Pickart L, Margolina A. (2018). Int J Mol Sci
Pickart L, et al. (2015). BioMed Research International
Reviews
Pickart L, et al. (2012). Oxid Med Cell Longev
Gorouhi F, Maibach HI. (2009). Int J Cosmet Sci
Maquart FX, et al. (2005). Biochimie
Clinical
Lee WJ, et al. (2016). Ann Dermatol
Mulder GD, et al. (1994). Wound Repair Regen
Primary research
Mao S, et al. (2025). Front Pharmacol
Greco V, et al. (2025). Bioconjug Chem
Bian Y, et al. (2024). Redox Biology
Zhang Q, et al. (2022). Front Mol Biosci
Ma WH, et al. (2020). Life Sciences
Klontzas ME, et al. (2019). Acta Biomaterialia
Choi HR, et al. (2012). J Pept Sci
Campbell JD, et al. (2012). Genome Medicine
Hureau C, et al. (2011). Chem Eur J
Gul NY, et al. (2008). Vet Dermatol
Arul V, et al. (2007). Life Sciences
Cangul IT, et al. (2006). Vet Dermatol
Canapp SO, et al. (2003). Vet Surg
Conato C, et al. (2001). Biochim Biophys Acta
Siméon A, et al. (2000). J Invest Dermatol
Siméon A, et al. (2000). Life Sciences
Maquart FX, et al. (1993). J Clin Invest
Wegrowski Y, et al. (1992). Life Sciences
Maquart FX, et al. (1988). FEBS Letters
Lau SJ, Sarkar B. (1981). Biochem J
Pickart L, et al. (1980). Nature
Schlesinger DH, et al. (1977). Experientia
Pickart L, Thaler MM. (1973). Nature New Biology
Also known as: Copper tripeptide-1, Cu-GHK
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
| Compound | Type | Molecular weight | CAS number |
|---|---|---|---|
| GHK-CuThis page | Tripeptide copper(II) complex | ~403.9 g/mol (free GHK ligand 340.4 g/mol) | 89030-95-5 |
| BPC-157 + TB-500 + GHK-Cu | Peptide blend | — | — |
| Melanotan I | Synthetic peptide (linear tridecapeptide) | ~1,646.9 g/mol | 75921-69-6 |
| SNAP-8 | Synthetic octapeptide (8 amino acids) | 1073.2 g/mol | 868844-74-0 |
| AHK-Cu | Synthetic copper(II)–tripeptide coordination complex | ~416.9 g/mol (AHK-Cu complex); free AHK tripeptide 354.40 g/mol | 682809-81-0 |
Comparison of laboratory reference specifications only. For research use only; not a therapeutic comparison.
Quality & methods