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Dermal
A synthetic linear tridecapeptide analogue of alpha-MSH carrying Nle4 and D-Phe7 substitutions, characterized in receptor structural-biology research.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Type
Synthetic peptide (linear tridecapeptide)
Molecular formula
C78H111N21O19
Molecular weight
~1,646.9 g/mol
CAS number
75921-69-6
Amino acids
13
Sequence
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Modification
N-terminal acetylation; C-terminal amide; Nle4 and D-Phe7 substitutions.
A linear tridecapeptide analogue of alpha-MSH carrying Nle4 and D-Phe7 substitutions, with N-terminal acetylation and a C-terminal amide. It is characterized as a ligand of a Gs-coupled G-protein-coupled receptor; cryo-EM studies of the receptor–Gs complex have resolved the orthosteric binding pocket and described how a peptide of this class occupies the receptor transmembrane bundle. The Nle4 and D-Phe7 substitutions confer protease resistance, and structural studies have examined how these substitutions affect binding geometry within the orthosteric pocket. The molecule retains the conserved His-Phe-Arg-Trp sequence motif central to its receptor-binding geometry.
Lyophilized
20°C, protected from light and moisture
stable long term.
Avoid freeze-thaw; protect from light; aqueous solution stored cold.
Reviews
Polańska A, et al. (2024). Postepy Dermatol Alergol
Lyseng-Williamson KA (2016). Am J Clin Dermatol
Wolf Horrell EM, Boulanger MC, D'Orazio JA (2016). Front Genet
Reviews
Herraiz C, et al. (2017). Biochim Biophys Acta Mol Basis Dis
Wu J, Cotliar R (2021). J Drugs Dermatol
Clinical
Langendonk JG, et al. (2015). N Engl J Med
Lim HW, et al. (2014). JAMA Dermatol
Biolcati G, et al. (2015). Br J Dermatol
Haylett AK, et al. (2011). Br J Dermatol
Barman-Aksozen J, et al. (2020). Orphanet J Rare Dis
Wensink D, et al. (2020). JAMA Dermatol
Lengweiler S, et al. (2015). Skin Pharmacol Physiol
Bohm M, Ehrchen J, Luger TA (2014). J Eur Acad Dermatol Venereol
Biolcati G, et al. (2013). Clin Exp Dermatol
Grimes PE, et al. (2013). JAMA Dermatol
Toh JJH, et al. (2020). J Am Acad Dermatol
Leaf RK, et al. (2024). Life (Basel)
Minder AE, et al. (2023). Life (Basel)
Primary research
Peake M, Rutter K, Griffin L, et al. (2024). J Invest Dermatol
Ma S, Chen Y, Dai A, et al. (2021). Cell Res
Minder EI, Barman-Aksoezen J, Schneider-Yin X (2017). Clin Pharmacokinet
Also known as: NDP-MSH
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
| Compound | Type | Molecular weight | CAS number |
|---|---|---|---|
| Melanotan IThis page | Synthetic peptide (linear tridecapeptide) | ~1,646.9 g/mol | 75921-69-6 |
| GHK-Cu | Tripeptide copper(II) complex | ~403.9 g/mol (free GHK ligand 340.4 g/mol) | 89030-95-5 |
| BPC-157 + TB-500 + GHK-Cu | Peptide blend | — | — |
| SNAP-8 | Synthetic octapeptide (8 amino acids) | 1073.2 g/mol | 868844-74-0 |
| AHK-Cu | Synthetic copper(II)–tripeptide coordination complex | ~416.9 g/mol (AHK-Cu complex); free AHK tripeptide 354.40 g/mol | 682809-81-0 |
Comparison of laboratory reference specifications only. For research use only; not a therapeutic comparison.
Quality & methods