Dermal
A melanocortin-pathway peptide studied in preclinical research.
Melanotan I is studied for how the body produces skin pigment (melanin) and shields skin from UV light. It is a lab-made analogue of the natural alpha-MSH hormone that mainly activates the MC1R receptor on pigment cells, which is why it appears in preclinical research on melanin production and photoprotection.
Type
Synthetic peptide (linear tridecapeptide)
Molecular formula
C78H111N21O19
Molecular weight
~1,646.9 g/mol
CAS number
75921-69-6
Amino acids
13
Sequence
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Modification
N-terminal acetylation; C-terminal amide; Nle4 and D-Phe7 substitutions.
A linear, acetylated, C-amidated tridecapeptide analogue of alpha-MSH carrying Nle4 and D-Phe7 substitutions; a melanocortin-receptor agonist binding predominantly to MC1R. Retains the conserved His-Phe-Arg-Trp motif.
Research Focus
Studied in melanocortin/MC1R pharmacology and melanogenesis/photoprotection research.
Lyophilized
-20°C, protected from light and moisture
stable long term.
Reconstituted
2-8°C, days to weeks
-20°C for longer aliquots.
Avoid freeze-thaw; protect from light; aqueous solution stored cold.
Lyseng-Williamson KA (2016). Am J Clin Dermatol
Also known as: NDP-MSH
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
