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For Research Purposes Only
Out of StockACE-031
Third-Party TestedPurity Standards
Total
$89.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Recombinant Fc-fusion protein (ActRIIB extracellular domain - human IgG1 Fc; disulfide-linked homodimer)
Molecular weight
~58.4 kDa per monomer (glycosylated)
CAS number
1169766-01-1
Amino acids
343
Modification
Disulfide-linked homodimer. Each 343-residue chain comprises the ACVR2B extracellular domain (residues 1-115), a triglycyl linker (116-118), and a human IgG1 Fc (119-343); seven intrachain disulfide bridges per chain, two interchain disulfide bridges joining the two chains, and three N-glycosylation sites per chain.
Mechanism & Target Class
Mechanism & Target Class
A soluble decoy receptor. The extracellular ACVR2B domain binds circulating TGF-beta superfamily ligands - myostatin (GDF-8), activin A, activin B, and GDF-11 - so that they do not engage membrane-bound type II activin receptors and recruit type I receptors (ALK4/ALK5), modulating SMAD2/3 signaling in the activin-receptor pathway in skeletal muscle. The construct also binds the vascular regulators BMP-9/BMP-10, with comparatively lower affinity for BMP-2/BMP-7. The IgG1 Fc drives dimerization and confers extended circulation.
Storage & Handling
Storage & Handling
Lyophilized
20C (-80C long term)
supplied lyophilized. Lyophilized powder is stable when kept sealed and dry.
Aliquot to minimize freeze-thaw; protect from light; confirm handling against the specific lot Certificate of Analysis.
References
References
Reviews
- 1
Lee SJ. (2023). Annual Review of Physiology
- 2
Rybalka E, et al. (2020). Cells
Reviews
- 3
Suh J, Lee YS. (2020). Journal of Bone Metabolism
Clinical
- 4
Campbell C, et al. (2017). Muscle & Nerve
- 5
Attie KM, et al. (2013). Muscle & Nerve
- 6
ClinicalTrials.gov (A031-01). ClinicalTrials.gov
- 7
ClinicalTrials.gov (A031-02). ClinicalTrials.gov
- 8
ClinicalTrials.gov (A031-03). ClinicalTrials.gov
- 9
ClinicalTrials.gov (A031-06). ClinicalTrials.gov
Primary research
- 10
Reichel C, et al. (2025). Drug Testing and Analysis
- 11
Lach-Trifilieff E, et al. (2014). Molecular and Cellular Biology
- 12
Pistilli EE, et al. (2011). American Journal of Pathology
- 13
Cadena SM, et al. (2010). Journal of Applied Physiology
- 14
Sako D, et al. (2010). Journal of Biological Chemistry
- 15
Zhou X, et al. (2010). Cell
- 16
Koncarevic A, et al. (2010). Endocrinology
- 17
Pistilli EE, et al. (2010). American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
- 18
Lee SJ, et al. (2005). Proceedings of the National Academy of Sciences
- 19
Lee SJ, McPherron AC. (2001). Proceedings of the National Academy of Sciences
Primary Database
Primary Database
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
