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For Research Purposes Only
Out of StockCardiogen
Third-Party TestedPurity Standards
Total
$64.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Synthetic linear tetrapeptide (short peptide bioregulator)
Molecular formula
C18H31N7O9
Molecular weight
489.5 g/mol
Amino acids
4
Sequence
Ala-Glu-Asp-Arg (AEDR); systematic form H-Ala-Glu-Asp-Arg-OH
Modification
None (unmodified free peptide: free N-terminus, free C-terminus)
Mechanism & Target Class
Mechanism & Target Class
Cardiogen belongs to the class of ultra-short regulatory peptides (2–4 residues) termed peptide bioregulators. Its sequence contains acidic residues (Glu, Asp) and a basic residue (Arg), giving it a charged, amphiphilic character proposed to support interaction with nucleic acids and nuclear proteins. The mechanistic hypothesis examined for this peptide class is that short peptides can enter cells and the nucleus without a classical carrier and interact site-specifically with DNA — including methylated CNG/CG-containing sequences — and with N-terminal regions of histones, thereby influencing the accessibility of gene-promoter regions and the activity of DNA-processing enzymes. In structural and biophysical work, short peptides of this class have been modeled as binding the minor groove of double-stranded DNA. These proposals are derived from in vitro and in silico systems; the precise promoter sequences engaged by AEDR in cardiac cells have not been fully characterized in the published literature.
Storage & Handling
Storage & Handling
Lyophilized
Store sealed and protected from light, frozen (−20 °C, or colder for long-term storage), and desiccated.
As a small unmodified linear peptide with charged residues, susceptible to proteolysis and degradation from heat, light, and repeated freeze–thaw. Handle using standard aseptic technique. For research use only.
References
References
Reviews
- 1
Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR (2021). Molecules
- 2
Khavinson VKh, Lin'kova NS, Tarnovskaya SI (2016). Bulletin of Experimental Biology and Medicine
Reviews
- 3
Anisimov VN, Khavinson VKh (2010). Biogerontology
- 4
Khavinson VKh, Anisimov VN (2009). Bull Exp Biol Med
- 5
Khavinson V, Linkova N, Dyatlova A, Kantemirova R, Kozlov K (2022). Cells
Primary research
- 6
Fedoreyeva LI, Smirnova TA, Kolomijtseva GY, Khavinson VKh, Vanyushin BF (2013). Biochemistry (Moscow)
- 7
Khavinson VKh, Tarnovskaya SI, Linkova NS, Pronyaeva VE, Shataeva LK, Yakutseni PP (2013). Bulletin of Experimental Biology and Medicine
- 8
Khavinson VKh, Lin'kova NS, Polyakova VO, Kvetnoy IM, Benberin VV, D'yakonov MM, Titkov YS (2012). Bulletin of Experimental Biology and Medicine
- 9
Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF (2011). Biochemistry (Moscow)
- 10
Khavinson VKh, Fedoreyeva LI, Vanyushin BF (2011). Bulletin of Experimental Biology and Medicine
- 11
Khavinson VKh, Ryzhak GA, Grigoriev EI, Ryadnova IYu (2010). United States Patent US 7,662,789 B2
- 12
Levdik NV, Knyazkin IV (2009). Bulletin of Experimental Biology and Medicine
- 13
Chalisova NI, Lesniak VV, Balykina NA, Urt'eva SA, Urt'eva TA, Sukhonos IuA, Zhekalov AN (2009). Advances in Gerontology
- 14
Zakutskii AN, Chalisova NI, Ryzhak GA, Aniskina AI, Filippov SV, Zeziulin PN (2006). Advances in Gerontology
- 15
Khavinson VKh, Solovyov AYu, Shataeva LK (2008). Bull Exp Biol Med
- 16
Ashapkin VV, Linkova NS, Khavinson VKh, Vanyushin BF (2015). Biochemistry (Moscow)
- 17
Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B (2020). Molecules
- 18
Lin'kova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VKh (2016). Bull Exp Biol Med
- 19
Fridman NV, Linkova NS, Kozhevnikova EO, Gutop EO, Khavinson VKh (2020). Bull Exp Biol Med
- 20
Ryzhak AP, Chalisova NI, Lin'kova NS, Nichik TE, Dudkov AV, Kolchina NV, Ryzhak GA, Khalimov RI (2017). Bull Exp Biol Med
- 21
Chalisova NI, Lin'kova NS, Nichik TE, Ryzhak AP, Dudkov AV, Ryzhak GA (2015). Bull Exp Biol Med
- 22
Lin'kova NS, Polyakova VO, Trofimov AV, Kvetnoy IM, Khavinson VKh (2011). Bull Exp Biol Med
Primary Database
Primary Database
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
