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Type
Porcine brain-derived neuropeptide and amino-acid preparation (enzymatic hydrolysate; heterogeneous mixture)
Molecular formula
n/a — heterogeneous mixture
Molecular weight
Peptide fraction <10 kDa
CAS number
12656-61-0
Modification
Enzymatic proteolysis and standardized fractionation of purified porcine brain proteins; no synthetic chemical modification.
A heterogeneous preparation of low-molecular-weight peptides and free amino acids derived by standardized enzymatic proteolysis of purified porcine brain proteins. The peptide fraction is below approximately 10 kDa. Independent mass-spectrometry profiling (HPLC-ESI ion-trap and UHPLC-ion-mobility-QTOF) identified the main peptide constituents as derived from structural proteins (tubulin, actin, myelin basic protein); intact endogenous neurotrophic-factor fragments were not detected in that analysis. As a peptide-containing hydrolysate, its constituents are subject to enzymatic degradation rather than being stable to oral exposure.
Lyophilized
Store per supplier specification
protect from light and moisture; lyophilized material typically stored at -20°C.
The preparation is parenterally administered and not orally stable; peptide constituents are degraded in the gastrointestinal tract.
Reviews
Patel PN, Mangal D, Patel K. (2025). Cureus
Ziganshina LE, Abakumova T, Nurkhametova D, Ivanchenko K. (2023). Cochrane Database of Systematic Reviews
Reviews
Rejdak K, Sienkiewicz-Jarosz H, Bienkowski P, Alvarez XA. (2023). Medicinal Research Reviews
Ziganshina LE, Abakumova T, Vernay L. (2020). Cochrane Database of Systematic Reviews
Cui S, Chen N, Yang M, Guo J, Zhou M, Zhu C, He L. (2019). Cochrane Database of Systematic Reviews
Gauthier S, Proaño JV, Jia J, Froelich L, Vester JC, Doppler E. (2015). Dementia and Geriatric Cognitive Disorders
Chen N, Yang M, Guo J, Zhou M, Zhu C, He L. (2013). Cochrane Database of Systematic Reviews
Clinical
Naseer MA, Dahshan A, Rabah A, Fouad AM, et al. (2023). Journal of Endocrinology and Diabetes
Vester JC, Buzoianu AD, Florian SI, et al. (2021). Neurological Sciences
Muresanu DF, Florian S, Hömberg V, et al. (2020). Neurological Sciences
Poon W, Matula C, Vos PE, Muresanu DF, et al. (2020). Neurological Sciences
Ashrafi MR, Mohammadi M, Vafaee-Shahi M, Tavasoli AR, Badv RS, et al. (2019). Iranian Journal of Pediatrics
Guekht A, Vester J, Heiss WD, Gusev E, Hoemberg V, Rahlfs VW, et al. (2017). Neurological Sciences
Muresanu DF, Heiss WD, Hoemberg V, Bajenaru O, Popescu CD, Vester JC, et al. (2016). Stroke
Lang W, Stadler CH, Poljakovic Z, Fleet D; Lyse Study Group. (2013). International Journal of Stroke
Heiss WD, Brainin M, Bornstein NM, Tuomilehto J, Hong Z; CASTA Investigators. (2012). Stroke
Alvarez XA, Cacabelos R, Sampedro C, Couceiro V, Aleixandre M, Vargas M, et al. (2011). Current Alzheimer Research
Hong Z, Moessler H, Bornstein N, Brainin M, Heiss WD; CASTA Investigators. (2009). International Journal of Stroke
Alvarez XA, Cacabelos R, Laredo M, et al. (2006). European Journal of Neurology
Gorbachevskaya N, Bashina V, Gratchev V, Iznak A. (2001). Brain & Development
Primary research
Mishra et al. (2024). Cureus
Yang B, Li Y, Guo W, Zhang Q, Pan L, Duan K, et al. (2023). Journal of Chromatography B
Kang DH, Choi BY, Lee SH, Kho AR, Jeong JH, Hong DK, et al. (2020). Frontiers in Neuroscience
Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, et al. (2015). Journal of Experimental Neuroscience
Gevaert B, D'Hondt M, Bracke N, Yao H, Wynendaele E, Vissers JPC, et al. (2015). Drug Testing and Analysis
Guan X, Wang Y, Kai G, Zhao S, Huang T, Li Y, et al. (2019). Frontiers in Pharmacology
Dong Y, et al. (2016). Neural Regeneration Research
Tincer G, et al. (2008). Journal of Neural Transmission
Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E. (2007). Acta Neuropathologica
Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, et al. (2006). Journal of Neuroscience Research
Hartbauer M, Hutter-Paier B, Skofitsch G, Windisch M. (2001). Journal of Neural Transmission
Rockenstein E, Adame A, Mante M, Moessler H, Windisch M, Masliah E. (2003). Journal of Neural Transmission
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