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For Research Purposes Only
Out of StockGonadorelin
Third-Party TestedPurity Standards
Total
$34.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Synthetic peptide (linear decapeptide, 10 residues)
Molecular formula
C55H75N17O13
Molecular weight
~1,182.3 Da
CAS number
33515-09-2
Amino acids
10
Sequence
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂
Modification
Pyroglutamate (pGlu) at the N-terminus; C-terminal glycinamide amidation. Both modifications are critical for receptor recognition and confer relative resistance to aminopeptidase and carboxypeptidase cleavage; primary plasma degradation occurs at the Gly6 position.
Mechanism & Target Class
Mechanism & Target Class
Gonadorelin is a synthetic linear decapeptide that engages a seven-transmembrane Gq/G11-coupled class A GPCR as a structural binding partner. The cognate receptor is unusual among GPCRs in lacking a cytoplasmic C-terminal tail, a structural feature that slows β-arrestin-mediated internalization and is studied as the basis for frequency-dependent receptor behavior. Upon ligand binding, the structurally characterized coupling proceeds through phospholipase C-β, which hydrolyzes PIP₂ into IP₃ and DAG; IP₃ mobilizes intracellular Ca²⁺ and DAG activates protein kinase C in cell-based assay models. A defining property characterized in the literature is pulse-dependent receptor pharmacology: intermittent exposure and continuous receptor occupancy produce distinct receptor states, with sustained occupancy driving GRK-mediated phosphorylation, β-arrestin recruitment, receptor internalization, and progressive surface-density downregulation. The pyroglutamate N-terminus and C-terminal glycinamide are essential for receptor recognition and confer relative resistance to exopeptidase cleavage; primary plasma degradation occurs at the Gly6 position, contributing to ultrashort circulatory clearance.
Storage & Handling
Storage & Handling
Lyophilized
20°C (−80°C recommended for long-term)
lyophilized powder stable approximately 24 months under proper conditions.
Hygroscopic; keep sealed and dry. Protect from light and moisture. Aliquot to minimize freeze-thaw exposure.
References
References
Reviews
- 1
Naelitz BD, Momtazi-Mar N, Lundy SD, et al. (2025). Nature Reviews Urology
- 2
Robin G, Dumont A, et al. (2014). Gynécologie Obstétrique & Fertilité
Reviews
- 3
Flanagan CA, Manilall A (2017). Front Endocrinol (Lausanne)
- 4
Naor Z, Harris D, Shacham S (1998). Front Neuroendocrinol
- 5
Naor Z (2009). Front Neuroendocrinol
- 6
Stamatiades GA, Carroll RS, Kaiser UB (2019). Endocrinology
- 7
McArdle CA, Franklin J, Green L, Hislop JN (2002). J Endocrinol
- 8
McArdle CA, Davidson JS, Willars GB (1999). Mol Cell Endocrinol
- 9
Constantin S, Bjelobaba I, Stojilkovic SS (2022). Curr Opin Pharmacol
- 10
Plant TM (2019). F1000Res
- 11
Okamura H, Tsukamura H, Ohkura S, et al. (2013). Adv Exp Med Biol
- 12
Boehm U, Bouloux PM, Dattani MT, et al. (2015). Nat Rev Endocrinol
- 13
Fanis P, Neocleous V, Papapetrou I, Phylactou LA, Skordis N (2023). Int J Mol Sci
Clinical
- 14
Sun QH, Zheng Y, Zhang XL, Mu YM (2015). Chin Med J (Engl)
- 15
Kim YJ, Hwangbo J, Park KH, et al. (2024). Ann Pediatr Endocrinol Metab
- 16
Quaas P, Quaas AM, Fischer M, De Geyter C (2022). J Assist Reprod Genet
- 17
Hao M, Mao JF, Guan QB, et al. (2021). Ann Transl Med
Primary research
- 18
Mao JF, et al. (2017). Asian Journal of Andrology
- 19
Willars GB, Heding A, Vrecl M, et al. (1999). J Biol Chem
- 20
Hislop JN, Everest HM, Flynn A, et al. (2001). J Biol Chem
- 21
Pawson AJ, Faccenda E, Maudsley S, et al. (2008). Endocrinology
- 22
Caunt CJ, Hislop JN, Kelly E, et al. (2004). Endocrinology
- 23
Burger LL, Dalkin AC, Aylor KW, Haisenleder DJ, Marshall JC (2002). Endocrinology
- 24
Lim S, Pnueli L, Tan JH, Naor Z, Rajagopal G, Melamed P (2009). PLoS One
Primary Database
Primary Database
Also known as: GnRH, GnRH-I, LHRH, gonadoliberin, luliberin
View this compound in the Research Library →Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
