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Out of StockHGH Fragment 176-191
Third-Party TestedPurity Standards
Total
$39.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Synthetic peptide (cyclic, 16 residues)
Molecular formula
C78H123N23O22S2
Molecular weight
~1,817 g/mol
CAS number
66004-57-7
Amino acids
16
Sequence
FLRIVQCRSVEGSCGF
Modification
Unmodified C-terminal hGH fragment (no N-terminal tyrosine extension); intramolecular Cys7–Cys14 disulfide bond forming a cyclic (7→14) loop. This distinguishes it from AOD-9604, the Tyr-extended modified analog.
Mechanism & Target Class
Mechanism & Target Class
A disulfide-cyclized 16-residue peptide corresponding to the C-terminal segment of a 191-residue parent protein, closed by a single intramolecular Cys7–Cys14 disulfide bond into a cyclic (7→14) loop. The published primary literature places the sequence at residues 177–191; "176-191" is the widespread secondary-literature nomenclature for the same fragment. NMR conformational analysis of the cyclic peptide identifies type I β-turns and describes how the Cys–Cys loop constrains the backbone. It is the native, unmodified parent of the later analog AOD-9604, which adds an N-terminal tyrosine extension; the present fragment carries no such extension.
Storage & Handling
Storage & Handling
Lyophilized
20 °C or colder, protected from light and moisture
stable for extended periods when kept frozen and sealed.
Avoid repeated freeze–thaw cycles; protect from light and moisture; the Cys7–Cys14 disulfide is oxidation-sensitive — avoid reducing agents. As the unmodified fragment, it lacks the N-terminal tyrosine that the AOD-9604 analog uses to improve stability.
References
References
Reviews
- 1
Kopchick JJ, et al. (2020). Nat Rev Endocrinol
- 2
Vijayakumar A, et al. (2010). Growth Horm IGF Res
Reviews
- 3
Mendias CL, Awan TM. (2026). Sports Medicine
- 4
Liao HJ, et al. (2024). Cartilage
- 5
Moré MI, Kenley D. (2014). Journal of Endocrinology and Metabolism
- 6
Stier H, Vos E, Kenley D. (2013). Journal of Endocrinology and Metabolism
Primary research
- 7
Wu Z, Ng FM. (1993). Biochem Mol Biol Int
- 8
Wijaya E, Ng FM. (1993). Biochem Mol Biol Int
- 9
Ng FM, et al. (2000). J Mol Endocrinol
- 10
Ng FM, et al. (2000). Horm Res
- 11
Heffernan MA, et al. (2000). Am J Physiol Endocrinol Metab
- 12
Ogru E, et al. (2000). J Pept Res
- 13
Heffernan M, et al. (2001). Endocrinology
- 14
Heffernan MA, et al. (2001). Int J Obes
- 15
Dietz J, Schwartz J. (1991). Metabolism
- 16
Sharma VM, et al. (2019). Am J Physiol Endocrinol Metab
- 17
Høyer KL, et al. (2020). Physiol Rep
- 18
Zhao L, Jiang H. (2023). Front Endocrinol
- 19
Huang J, et al. (2023). Endocrinology
- 20
Cox HD, et al. (2015). Drug Test Anal
- 21
Vanhee C, et al. (2014). Drug Test Anal
- 22
Orlovius AK, et al. (2013). Drug Test Anal
- 23
Kwon DR, Park GY. (2015). Ann Clin Lab Sci
- 24
Ng FM, Bornstein J. (1978). American Journal of Physiology
Primary Database
Primary Database
Also known as: hGH 176-191, hGH Fragment 177-191, Somatotropin (176-191), AOD-9401
View this compound in the Research Library →Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
