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For Research Purposes Only
Out of StockHumanin
Third-Party TestedPurity Standards
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$79.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Mitochondria-derived peptide (MDP; 21–24 residues depending on translation context)
Molecular formula
C₁₁₉H₂₀₄N₃₄O₃₂S₂
Molecular weight
~2,687 g/mol
CAS number
330936-69-1
Amino acids
24
Sequence
MAPRGFSCLLLLTSEIDLPVKRRA
Modification
Cytosolic translation yields the 24-residue canonical sequence (MAPRGFSCLLLLTSEIDLPVKRRA; UniProt Q8IVG9); mitochondrial translation yields a 21-residue form (MAPRGFSCLLLLTSEIDLPVK) due to differences in the mitochondrial genetic code. Both forms have been studied. Commonly used research analogs include the S14G substitution (HNG, studied for extended in vivo stability), N-formylated Humanin (fHN, studied for receptor pharmacology), the F6A/HNGF6A substitution (abolishes IGFBP-3 binding — used to dissect interaction specificity), and D-Ser14 forms (structural studies). Cys8 and Leu12 are noted as functionally critical residues in mechanistic work.
Mechanism & Target Class
Mechanism & Target Class
Humanin has been studied as a peptide with both intracellular and extracellular binding partners. Intracellularly, it has been characterized as a binding partner for Bcl-2-family proteins — including BAX, BID/tBID, and BimEL — and for IGFBP-3; structural studies demonstrate that Humanin can induce conformational changes in BAX and recruit it into higher-order β-sheet fiber assemblies, work that provides structural context for the mitochondrial outer-membrane permeabilization (MOMP) literature. Extracellularly, it has been examined as a ligand at members of the G-protein-coupled receptor (GPCR) family and at a trimeric cytokine-receptor complex; cryo-EM and biophysical studies have resolved receptor-bound forms at atomic resolution, mapping the binding interface and the structural basis for competitive ligand models.
Storage & Handling
Storage & Handling
Lyophilized
20°C (-80°C long term)
lyophilized powder typically stable ~24 months under dry, sealed conditions.
Native Humanin is reported to have a short circulating half-life in vivo that varies by species and analog form; the S14G (HNG) analog has been studied for extended in vivo stability in animal models. Protect from light and moisture; Cys8 is an oxidation-sensitive residue.
References
References
Reviews
- 1
Karachaliou CE, Livaniou E. (2023). Biology (Basel)
- 2
Systematic review. (2023). Biology (Basel)
Reviews
- 3
Miller B, Kim SJ, Kumagai H, et al. (2022). J Clin Invest
- 4
Lee C, Yen K, Cohen P. (2013). Trends Endocrinol Metab
- 5
Yen K, Lee C, Mehta H, Cohen P. (2013). J Mol Endocrinol
Clinical
- 6
Miller B, Kim SJ, Cao K, et al. (2024). Aging Cell
- 7
Yen K, Wan J, Mehta HH, et al. (2018). Sci Rep
Primary research
- 8
Zhu Y, Lin X, Zong X, et al. (2022). Nat Commun
- 9
Yen K, Mehta HH, Kim SJ, et al. (2020). Aging (Albany NY)
- 10
Morris DL, Kastner DW, Johnson S, et al. (2019). J Biol Chem
- 11
Kuliawat R, Klein L, Gong Z, et al. (2013). FASEB J
- 12
Muzumdar RH, Huffman DM, Calvert JW, et al. (2010). Arterioscler Thromb Vasc Biol
- 13
Muzumdar RH, Huffman DM, Atzmon G, et al. (2009). PLoS One
- 14
Hashimoto Y, Kurita M, Aiso S, Nishimoto I, Matsuoka M. (2009). Mol Biol Cell
- 15
Luciano F, Zhai D, Zhu X, et al. (2005). J Biol Chem
- 16
Zhai D, Luciano F, Zhu X, Guo B, Satterthwait AC, Reed JC. (2005). J Biol Chem
- 17
Harada M, Habata Y, Hosoya M, et al. (2004). Biochem Biophys Res Commun
- 18
Ying G, Iribarren P, Zhou Y, et al. (2004). J Immunol
- 19
Guo B, Zhai D, Cabezas E, et al. (2003). Nature
- 20
Ikonen M, Liu B, Hashimoto Y, et al. (2003). Proc Natl Acad Sci USA
- 21
Hashimoto Y, Niikura T, Ito Y, et al. (2001). J Neurosci
- 22
Hashimoto Y, Niikura T, Tajima H, et al. (2001). Proc Natl Acad Sci USA
Primary Database
Primary Database
Also known as: HN, MT-RNR2 peptide, mitochondria-derived peptide
View this compound in the Research Library →Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
