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For Research Purposes Only
Out of StockKisspeptin-10
Third-Party TestedPurity Standards
Total
$29.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Linear decapeptide (C-terminally amidated), RF-amide peptide family
Molecular formula
C63H83N17O14
Molecular weight
1302.4 g/mol
CAS number
374675-21-5
Amino acids
10
Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Modification
C-terminal amidation (RF-amide motif)
Mechanism & Target Class
Mechanism & Target Class
Kisspeptin-10 is a linear decapeptide corresponding to the conserved C-terminal segment shared by the four naturally occurring kisspeptins (KP-54, KP-14, KP-13, KP-10), all of which terminate in an arginine-phenylalanine-amide (RF-amide) motif. C-terminal amidation is the single most critical structural determinant of the molecule's binding conformation, and structure-activity studies establish that the terminal amide is required for high-affinity engagement. Cryo-EM studies of KP-10 bound to its class A G-protein-coupled receptor complex define a three-segment binding mode in which the N-terminal residues (Tyr-Asn-Trp-Asn-Ser-Phe) sit between the receptor extracellular loops and the C-terminal RF-amide inserts into the transmembrane core (PDB 8ZJD), with Phe6, Arg9, and Phe10 identified as residues central to the interaction. KP-10 belongs to the RF-amide peptide family, alongside neuropeptide FF, prolactin-releasing peptide, and QRFP.
Storage & Handling
Storage & Handling
Lyophilized
Store lyophilized powder sealed and protected from light, heat, and moisture
long-term storage at -20°C is standard for peptide research materials.
As a small linear peptide, KP-10 is subject to enzymatic degradation in biological matrices; its in vivo plasma half-life is notably shorter than that of kisspeptin-54. Aliquoting is recommended to preserve integrity.
References
References
Reviews
- 1
Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M (2012). Physiological Reviews
- 2
Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M (2008). Frontiers in Neuroendocrinology
Clinical
- 3
George JT, Veldhuis JD, Roseweir AK, Newton CL, Faccenda E, Millar RP, Anderson RA (2011). Journal of Clinical Endocrinology & Metabolism
- 4
Jayasena CN, Nijher GM, Comninos AN, et al. (2011). Journal of Clinical Endocrinology & Metabolism
- 5
Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, Murphy KG, Badman MK, McGowan BM, Amber V, Patel S, Ghatei MA, Bloom SR (2005). Journal of Clinical Endocrinology & Metabolism
- 6
Seminara SB, Messager S, Chatzidaki EE, et al. (2003). New England Journal of Medicine
- 7
ClinicalTrials.gov. ClinicalTrials.gov
- 8
ClinicalTrials.gov. ClinicalTrials.gov
- 9
ClinicalTrials.gov. ClinicalTrials.gov
Primary research
- 10
Shen S, Wang D, Liu H, He X, Cao Y, Chen J, Li S, Cheng X, Xu HE, Duan J (2024). Cell Reports
- 11
Wu Z, Chen G, Qiu C, et al. (2024). Science Advances
- 12
Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP (2009). Journal of Neuroscience
- 13
Tomita K, Niida A, Oishi S, Ohno H, Cluzeau J, Navenot JM, Wang ZX, Peiper SC, Fujii N (2006). Bioorganic & Medicinal Chemistry
- 14
Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM (2005). PNAS
- 15
Messager S, Chatzidaki EE, Ma D, et al. (2005). PNAS
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Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA (2004). Endocrinology
- 17
Bilban M, Ghaffari-Tabrizi N, Hintermann E, Bauer S, Molzer S, Zoratti C, Malli R, Sharabi A, Hiden U, Graier W, et al. (2004). Journal of Cell Science
- 18
de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E (2003). PNAS
- 19
Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, et al. (2001). Journal of Biological Chemistry
- 20
Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, et al. (2001). Nature
- 21
Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, et al. (2001). Journal of Biological Chemistry
- 22
Lee JH, Miele ME, Hicks DJ, Phillips KK, Trent JM, Weissman BE, Welch DR (1996). Journal of the National Cancer Institute
Primary Database
Primary Database
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
