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For Research Purposes Only
Out of StockMolecular Profile
Molecular Profile
Type
Synthetic peptide (IGF-1Ec C-terminal E-domain, 24 residues)
Molecular formula
C121H199N41O40
Molecular weight
~2,868 g/mol
Amino acids
24
Sequence
YQPPSTNKNTKSQRRKGSTFEEHK
Modification
The synthetic research peptide corresponds to the free-acid 24-residue E-domain; stabilized analogs substitute D-arginine in the central basic (QRRK) region and amidate the C-terminus to slow proteolysis, and PEGylated forms (PEG-MGF) couple a polyethylene glycol chain to extend circulating half-life.
Mechanism & Target Class
Mechanism & Target Class
MGF is a synthetic peptide corresponding to the unique C-terminal E-domain of a mechanically inducible IGF-1 splice isoform, a structure generated when inclusion of a short exon-5 insert shifts the reading frame in exon 6 to produce a 24-residue sequence distinct from the predominant systemic isoform. A central, unresolved structural question in the literature is which receptor, if any, this E-domain peptide engages; no dedicated E-peptide binding partner has been definitively identified. The peptide's arginine/lysine-rich polybasic motif has been studied as a potential cell-penetrating and nuclear-localization element, and specific protein interactions (e.g., with 14-3-3 proteins in cardiac cell models) have been characterized.
Storage & Handling
Storage & Handling
Lyophilized
20°C (colder for long-term)
keep desiccated and frozen until use.
Minimize freeze-thaw cycles; protect from light; the unmodified peptide carries multiple basic residues and is handled in aqueous buffers.
References
References
Reviews
- 1
Vassilakos G, et al. (2014). Hormones (Athens)
- 2
Brisson BK, Barton ER. (2013). Frontiers in Endocrinology
Reviews
- 3
Matheny RW Jr, Nindl BC, Adamo ML. (2010). Endocrinology
- 4
Goldspink G. (2005). Physiology (Bethesda)
Clinical
- 5
Hameed M, et al. (2004). Journal of Physiology
- 6
Hameed M, et al. (2003). Journal of Physiology
Primary research
- 7
Solís C, et al. (2022). Frontiers in Physiology
- 8
Armakolas A, et al. (2015). Molecular Medicine
- 9
Fornaro M, et al. (2014). American Journal of Physiology-Endocrinology and Metabolism
- 10
Mavrommatis E, Shioura KM, Los T, Goldspink PH. (2013). Molecular and Cellular Biochemistry
- 11
Schlegel W, et al. (2013). PLOS ONE
- 12
Brisson BK, Barton ER. (2012). PLOS ONE
- 13
Deng M, et al. (2011). International Orthopaedics
- 14
Kandalla PK, Goldspink G, Butler-Browne G, Mouly V. (2011). Mechanisms of Ageing and Development
- 15
Armakolas A, et al. (2010). The Prostate
- 16
Stavropoulou A, et al. (2009). Molecular Medicine
- 17
Riddoch-Contreras J, et al. (2009). Experimental Neurology
- 18
Philippou A, et al. (2008). In Vivo
- 19
Carpenter V, et al. (2008). Heart, Lung and Circulation
- 20
Ates K, et al. (2007). FEBS Letters
- 21
Dłużniewska J, et al. (2005). FASEB Journal
- 22
Aperghis M, et al. (2004). Brain Research
- 23
Yang SY, Goldspink G. (2002). FEBS Letters
- 24
McKoy G, et al. (1999). Journal of Physiology
- 25
Yang S, Alnaqeeb M, Simpson H, Goldspink G. (1996). Journal of Muscle Research and Cell Motility
Primary Database
Primary Database
Also known as: Mechano Growth Factor, IGF-1Ec, MGF E-peptide, MGF-24aa
View this compound in the Research Library →Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
