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For Research Purposes Only
Out of StockOxytocin
Third-Party TestedPurity Standards
Total
$34.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Endogenous nonapeptide (disulfide-bridged, 9 residues)
Molecular formula
C43H66N12O12S2
Molecular weight
1,007.2 Da
CAS number
50-56-6
Amino acids
9
Sequence
CYIQNCPLG-NH2
Modification
Intramolecular disulfide bond between Cys1 and Cys6; C-terminal primary amide.
Mechanism & Target Class
Mechanism & Target Class
Oxytocin activates OXTR, a rhodopsin-family (class A) GPCR primarily coupled via Gq/11 to phospholipase C-β, which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3); IP3 triggers Ca²⁺ release from intracellular stores via IP3 receptors while DAG activates protein kinase C. OXTR can also engage Gi/o-family proteins under certain conditions. The high-affinity active state requires Mg²⁺ as a coordinating cofactor and cholesterol at an extrahelical allosteric site between transmembrane helices IV and V. OXTR shows pharmacological cross-reactivity with the closely related vasopressin receptor subtypes (V1aR, V1bR, V2R), a recognized confound in exogenous-administration studies. Structural studies have resolved the role of a single conserved residue acting as a molecular switch governing cation dependence across the oxytocin/vasopressin receptor family.
Storage & Handling
Storage & Handling
Lyophilized
20°C (-80°C long term)
lyophilized powder typically stable approximately 24 months.
Aliquot to avoid repeated freeze-thaw cycles; protect from light; maintain sealed and dry conditions.
References
References
Reviews
- 1
McCormack SE, et al. (2021). Int J Mol Sci
- 2
Lawson EA, et al. (2020). Endocr Rev
Reviews
- 3
Ooi YP, et al. (2017). Pharmacopsychiatry
- 4
Lawson EA. (2017). Nat Rev Endocrinol
- 5
Arrowsmith S, Wray S. (2014). J Neuroendocrinol
- 6
Preti A, et al. (2014). J Child Adolesc Psychopharmacol
- 7
Meyer-Lindenberg A, et al. (2011). Nat Rev Neurosci
- 8
Gimpl G, Fahrenholz F. (2001). Physiol Rev
Clinical
- 9
Sikich L, et al. (2021). N Engl J Med
- 10
Spanos M, et al. (2020). Contemp Clin Trials
- 11
Lee MR, et al. (2018). Mol Psychiatry
- 12
Striepens N, et al. (2013). Sci Rep
- 13
Kosfeld M, et al. (2005). Nature
- 14
Kirsch P, et al. (2005). J Neurosci
Primary research
- 15
Berendzen KM, et al. (2023). Neuron
- 16
Meyerowitz JG, et al. (2022). Nat Struct Mol Biol
- 17
Waltenspühl Y, et al. (2022). Nat Commun
- 18
Waltenspühl Y, et al. (2020). Sci Adv
- 19
Insel TR, Hulihan TJ. (1995). Behav Neurosci
- 20
Fuchs AR, et al. (1982). Science
Primary Database
Primary Database
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
