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For Research Purposes Only
Out of StockPEG-MGF
Third-Party TestedPurity Standards
Total
$64.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
PEGylated synthetic peptide (IGF-1 splice-variant E-domain, 24 residues)
Molecular weight
~2.7 kDa (unPEGylated peptide portion; approximate)
Amino acids
24
Sequence
YQPPSTNKNTKSQRRKGSTFEEHK
Modification
Covalent polyethylene-glycol conjugation of the 24-residue MGF E-peptide, intended to slow proteolysis and renal filtration of the small peptide; the PEG chain size, linker, and attachment site are not defined in primary sources. The unmodified peptide is the C-terminal E-domain of the IGF-1Ec splice variant (IGF-1Eb in rodents). Two sequence variants circulate: a synthetic analog ending …FEE-His-Lys (shown above) and the native human E-domain ending …FEE-Arg-Lys.
Mechanism & Target Class
Mechanism & Target Class
MGF is generated by alternative splicing of the IGF-1 gene: a reading-frame shift in the E-domain-encoding exon produces a unique C-terminal E-peptide that is absent from the more abundant IGF-1Ea isoform. The mature IGF-1 region is identical across the isoforms; the isolated 24-residue E-domain peptide is the entity synthesized as MGF, and PEG-MGF is that peptide conjugated to polyethylene glycol. A defining structural feature of the isolated E-peptide is that it lacks the mature IGF-1 region present in full-length constructs: in receptor-activation bioassays the isolated 24-residue peptide produces no detectable receptor-kinase activation, in contrast to full-length constructs that retain the mature IGF-1 region. This structural distinction is the basis of the long-standing and still-contested characterization of the isolated peptide as a molecule separate from mature IGF-1. The structural rationale offered for PEGylation is that the small (~2.7 kDa) peptide is otherwise rapidly filtered and proteolyzed.
Storage & Handling
Storage & Handling
Lyophilized
20°C
lyophilized powder typically stable months when kept desiccated and protected from light.
Small water-soluble peptide; protect from light; keep sealed and dry.
References
References
Reviews
- 1
Zabłocka B, Goldspink PH, Goldspink G, Górecki DC. (2012). Front Endocrinol (Lausanne)
- 2
Matheny RW Jr, Nindl BC, Adamo ML. (2010). Endocrinology
Reviews
- 3
Velloso CP, Harridge SDR. (2010). Scand J Med Sci Sports
- 4
Goldspink G. (2005). Int J Biochem Cell Biol
- 5
Goldspink G. (2005). Physiology (Bethesda)
- 6
Hill M, Wernig A, Goldspink G. (2003). J Anat
Clinical
- 7
Philippou A, et al. (2009). In Vivo
- 8
Hameed M, et al. (2004). J Physiol
- 9
Hameed M, et al. (2003). J Physiol
Primary research
- 10
medRxiv preprint. (2023). medRxiv
- 11
Mol Brain primary study. (2017). Mol Brain
- 12
Janssen JAMJL, et al. (2016). PLoS One
- 13
Fornaro M, et al. (2014). Am J Physiol Endocrinol Metab
- 14
Schlegel W, Raimann A, Halbauer D, et al. (2013). PLoS One
- 15
Mavrommatis E, Shioura KM, Los T, Goldspink PH. (2013). Mol Cell Biochem
- 16
Kravchenko IV, Furalyov VA, Popov VO. (2012). Mol Cell Biochem
- 17
Esposito S, Deventer K, Van Eenoo P. (2012). Rapid Commun Mass Spectrom
- 18
Kandalla PK, Goldspink G, Butler-Browne G, Mouly V. (2011). Mech Ageing Dev
- 19
Deng M, et al. (2011). Int Orthop
- 20
Stavropoulou A, et al. (2009). Mol Med
- 21
Carpenter V, et al. (2008). Heart Lung Circ
- 22
Mills P, Dominique JC, Lafrenière JF, Bouchentouf M, Tremblay JP. (2007). Am J Transplant
- 23
Ates K, et al. (2007). FEBS Lett
- 24
Dłużniewska J, et al. (2005). FASEB J
- 25
Cheema U, Brown R, Mudera V, Yang SY, McGrouther G, Goldspink G. (2005). J Cell Physiol
- 26
Hill M, Goldspink G. (2003). J Physiol
- 27
Yang SY, Goldspink G. (2002). FEBS Lett
- 28
McKoy G, et al. (1999). J Physiol
- 29
Yang S, Alnaqeeb M, Simpson H, Goldspink G. (1996). J Muscle Res Cell Motil
Primary Database
Primary Database
Also known as: Mechano Growth Factor (PEGylated), MGF E-peptide (PEGylated)
View this compound in the Research Library →Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
