LUV RT

Mechanism & Target Class

A single-peptide triple agonist built on a GIP/GLP-1/glucagon hybrid scaffold that engages three class B GPCRs — the GIP receptor (GIPR), the GLP-1 receptor (GLP-1R), and the glucagon receptor (GCGR). Cryo-EM structures of RT-10 bound to each receptor–Gs complex reveal a continuous α-helical conformation in which the N-terminal segment inserts into the receptor's transmembrane bundle and the central segment contacts extracellular loops. Non-standard residues (Aib, α-methyl-Leu) confer protease resistance; the C20 fatty-diacid side chain confers reversible albumin binding, extending circulatory half-life.

Research Focus

Studied in vitro and in preclinical models in the context of receptor pharmacology and metabolic disease research.