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For Research Purposes Only
Out of StockSelank / Semax
Third-Party TestedPurity Standards
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$49.99Size
Quantity
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Molecular Profile
Molecular Profile
Peptide blend
Selank
Molecular formula
C33H57N11O9
Molecular weight
~751.9 g/mol
CAS number
129954-34-3
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
Semax
Molecular formula
C37H51N9O10S
Molecular weight
~813.9 g/mol
CAS number
80714-61-0
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
Mechanism & Target Class
Mechanism & Target Class
Both peptides belong to the 'glyproline-stabilized' class: a short N-terminal sequence is extended with a C-terminal Pro-Gly-Pro (PGP) tripeptide that slows proteolysis. Selank corresponds structurally to the tetrapeptide tuftsin sequence (Thr-Lys-Pro-Arg) carrying the C-terminal PGP extension, giving the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro. Semax is a synthetic peptide corresponding to the ACTH(4-7) sequence (Met-Glu-His-Phe) carrying the same C-terminal PGP extension, giving the heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro; its N-terminal methionine residue is susceptible to oxidation. The shared PGP scaffold is the common structural feature characterized across both molecules, and the C-terminal glyproline motif is described in the chemistry literature as the modification that resists enzymatic degradation.
Storage & Handling
Storage & Handling
Lyophilized
Store frozen and protected from light and moisture
commonly handled at -20°C for long-term storage as a sealed lyophilized powder.
The C-terminal Pro-Gly-Pro motif confers resistance to enzymatic degradation; The methionine residue in Semax is susceptible to oxidation — protect from light and air. Avoid repeated freeze-thaw cycles. For research use only; not for human or veterinary use.
References
References
Reviews
- 1
Dergunova LV, Filippenkov IB, Limborska SA, et al. (2023). Genes (Basel)
- 2
Koroleva SV, Myasoedov NF. (2018). Biology Bulletin
Reviews
- 3
Vyunova TV, Andreeva L, Shevchenko K, Myasoedov N. (2018). Protein and Peptide Letters
Clinical
- 4
Gusev EI, Martynov MY, Kostenko EV, et al. (2018). Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
- 5
Medvedev VE, Tereshchenko ON, Kost NV, et al. (2015). Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
- 6
Zozulya AA, Neznamov GG, Syunyakov TS, et al. (2008). Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
- 7
Uchakina ON, Uchakin PN, Miasoedov NF, et al. (2008). Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
- 8
Gusev EI, Skvortsova VI, Miasoedov NF, et al. (1997). Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
Primary research
- 9
Inozemtseva LS, Yatsenko KA, Glazova NYu, et al. (2024). European Journal of Pharmacology
- 10
Panikratova YaR, Lebedeva IS, Sokolov OYu, et al. (2020). Doklady Biological Sciences
- 11
Filatova E, Kasian A, Kolomin T, et al. (2017). Frontiers in Pharmacology
- 12
Kasian A, Kolomin T, Andreeva L, et al. (2017). Behavioural Neurology
- 13
Volkova A, Shadrina M, Kolomin T, et al. (2016). Frontiers in Pharmacology
- 14
Medvedeva EV, Dmitrieva VG, Povarova OV, et al. (2014). BMC Genomics
- 15
Inozemtseva LS, Karpenko EA, Dolotov OV, et al. (2008). Doklady Biological Sciences
- 16
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. (2006). Brain Research
- 17
Eremin KO, Kudrin VS, Saransaari P, et al. (2005). Neurochemical Research
- 18
Kost NV, Sokolov OYu, Gabaeva MV, et al. (2001). Russian Journal of Bioorganic Chemistry
- 19
Zozulya AA, Kost NV, Sokolov OYu, et al. (2001). Bulletin of Experimental Biology and Medicine
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
