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Research updates from Luvaminos
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Cellular
A short synthetic tetrapeptide studied in telomere biology, chromatin research, and pineal neuroendocrine models.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Type
Synthetic linear tetrapeptide
Molecular formula
C14H22N4O9
Molecular weight
390.35 g/mol
CAS number
307297-39-8
Amino acids
4
Sequence
Ala-Glu-Asp-Gly (AEDG)
Modification
Free termini.
Epithalon (AEDG) is a four-residue peptide sufficiently small to enter the nucleus directly. Biophysical and molecular-docking work has examined interactions of the AEDG sequence with the DNA double helix and with linker histones H1/3 and H1/6, characterizing binding geometry and measuring chromatin-condensation state and nucleolar-organizer-region gene transcript levels as assay endpoints. The telomere biology literature has assayed hTERT gene expression and telomerase enzymatic activity in cell-culture models exposed to Epithalon; cancer-cell-line studies have additionally measured telomere dynamics through the alternative lengthening of telomeres (ALT) pathway. A separate body of work examines the peptide in neuroendocrine models, measuring melatonin synthesis and cortisol circadian-rhythm parameters in primate and human study designs.
Lyophilized
−20°C desiccated and light-protected
−80°C for long-term storage.
Hygroscopic short peptide; protect from light and moisture.
Reviews
Araj SK, et al. (2025). Int J Mol Sci
Khavinson VKh, et al. (2021). Molecules
Anisimov VN, Khavinson VKh. (2010). Biogerontology
Reviews
Khavinson VKh, et al. (2009). Bull Exp Biol Med
Khavinson VKh. (2002). Neuroendocrinol Lett
Clinical
Korkushko OV, et al. (2011). Bull Exp Biol Med
Labunets IF, et al. (2007). Bull Exp Biol Med
Korkushko OV, et al. (2006). Bull Exp Biol Med
Korkushko OV, et al. (2004). Bull Exp Biol Med
Korkushko OV, et al. (2004). Bull Exp Biol Med
Khavinson VKh, et al. (2002). Neuroendocrinol Lett
Primary research
Al-Dulaimi S, et al. (2025). Biogerontology
Gatta M, et al. (2025). Stem Cell Rev Rep
Ullah S, et al. (2025). Life Sci
Yue X, et al. (2022). Aging (Albany NY)
Khavinson V, et al. (2020). Molecules
Sinjari B, et al. (2020). Stem Cell Rev Rep
Khavinson VKh, et al. (2019). Bull Exp Biol Med
Vinogradova IA, et al. (2008). Bull Exp Biol Med
Khavinson VKh, et al. (2004). Bull Exp Biol Med
Khavinson VKh, et al. (2003). Bull Exp Biol Med
Khavinson VKh, et al. (2003). Bull Exp Biol Med
Anisimov VN, et al. (2003). Biogerontology
Anisimov VN, et al. (2002). Int J Cancer
Anisimov VN, et al. (2002). Cancer Lett
Goncharova ND, et al. (2001). Bull Exp Biol Med
Khavinson VKh, et al. (2001). Neuroendocrinol Lett
Anisimov VN, et al. (1992). Ann N Y Acad Sci
Also known as: Epitalon, AEDG peptide
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
| Compound | Type | Molecular weight | CAS number |
|---|---|---|---|
| EpithalonThis page | Synthetic linear tetrapeptide | 390.35 g/mol | 307297-39-8 |
| BPC-157 | Synthetic peptide (pentadecapeptide) | 1,419.5 g/mol | 137525-51-0 |
| TB-500 | Synthetic peptide (Thymosin Beta-4 related) | ~4,963 g/mol | 77591-33-4 |
| SS-31 | Synthetic aromatic-cationic tetrapeptide (C-terminally amidated, mitochondria-targeted) | 639.8 g/mol | 736992-21-5 |
| BPC-157 + TB-500 + GHK-Cu + KPV | Peptide blend | — | — |
Comparison of laboratory reference specifications only. For research use only; not a therapeutic comparison.
Quality & methods