Cellular
A tripeptide fragment investigated in preclinical cellular research.
KPV is studied in inflammation research. It is the small, active tail end (just three amino acids) of the natural alpha-MSH hormone, and in preclinical models researchers examine how it may quiet inflammatory signaling — particularly in the gut and skin — through pathways such as NF-kB.
Type
Synthetic peptide (tripeptide)
Molecular formula
C16H30N4O4
Molecular weight
342.43 g/mol
CAS number
67727-97-3
Amino acids
3
Sequence
Lys-Pro-Val (KPV)
Modification
Free termini; C-terminal tripeptide of alpha-MSH (residues 11-13).
The C-terminal tripeptide of alpha-melanocyte-stimulating hormone. Research associates it with uptake via the PepT1 (SLC15A1) peptide transporter and with NF-kB and MAPK signaling; reported activity in models is melanocortin-receptor-independent.
Research Focus
Studied in intestinal-inflammation, dermatological and immune-signaling (NF-kB) research models.
Lyophilized
-20°C
protect from light and moisture; ~24 months.
Reconstituted
2-8°C
days to weeks; avoid freeze-thaw.
Small soluble tripeptide; protect from moisture; aliquot.
Dalmasso G, et al. (2008). Gastroenterology
Brzoska T, et al. (2008). Endocr Rev
Also known as: alpha-MSH(11-13), Lys-Pro-Val
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
