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For Research Purposes Only
Out of StockHexarelin
Third-Party TestedPurity Standards
Total
$39.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Synthetic peptide (hexapeptide)
Molecular formula
C47H58N12O6
Molecular weight
887.04 g/mol
CAS number
140703-51-1
Amino acids
6
Sequence
His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH2
Modification
D-2-methyltryptophan; D-Phe; C-terminal amide.
Mechanism & Target Class
Mechanism & Target Class
A synthetic peptidyl hexapeptide of the GHRP series that engages two structurally distinct membrane-protein binding partners. The first is a class A G-protein-coupled receptor characterized in binding and photoaffinity-labeling studies of brain and pituitary membranes. The second is CD36, a heavily glycosylated class B membrane glycoprotein of roughly 472 residues, identified through photoaffinity cross-linking as a binding partner whose contact interface maps to a lysine-rich extracellular segment (residues Gln155-Lys183). The molecule's defining structural feature is substitution of the position-2 tryptophan of the parent GHRP-6 sequence with D-2-methyl-tryptophan, a non-canonical residue that confers conformational rigidity and resistance to proteolytic degradation; a conserved core and a turn-stabilized backbone are recurring pharmacophore elements across the GHRP series.
Storage & Handling
Storage & Handling
Lyophilized
20°C
typically stable 24-36 months desiccated.
Avoid freeze-thaw; aliquot; protect from light and moisture.
References
References
Reviews
- 1
Ishida J, et al. (2020). JCSM Rapid Communications
- 2
Proulx C, et al. (2020). Biomedicines
Reviews
- 3
Mao Y, et al. (2014). J Geriatr Cardiol
- 4
Demers A, et al. (2008). PPAR Research
Clinical
- 5
Arvat E, et al. (1997). Peptides
- 6
Arvat E, et al. (1997). Eur J Endocrinol
- 7
Ghigo E, et al. (1994). J Clin Endocrinol Metab
- 8
Imbimbo BP, et al. (1994). Eur J Clin Pharmacol
Primary research
- 9
McDonald H, et al. (2020). Biomed Pharmacother
- 10
Cheng XL, et al. (2019). Peptides
- 11
McDonald H, et al. (2018). Physiol Rep
- 12
Mao Y, et al. (2013). Endocrinology
- 13
Proulx C, et al. (2012). J Med Chem
- 14
Sabatino D, et al. (2011). J Am Chem Soc
- 15
Demers A, et al. (2004). Biochem J
- 16
Bodart V, et al. (2002). Circ Res
- 17
Tivesten Å, et al. (2000). Endocrinology
- 18
Locatelli V, et al. (1999). Endocrinology
- 19
Bodart V, et al. (1999). Circ Res
- 20
Muccioli G, et al. (1998). J Endocrinol
- 21
Torsello A, et al. (1996). Neuroendocrinology
- 22
Deghenghi R, et al. (1994). Life Sci
Primary Database
Primary Database
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
