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For Research Purposes Only
Out of StockMolecular Profile
Molecular Profile
Type
Pyridine-dinucleotide coenzyme
Molecular formula
C21H27N7O14P2
Molecular weight
663.43 g/mol
CAS number
53-84-9
Mechanism & Target Class
Mechanism & Target Class
NAD+ operates through two broad biochemical modes. As a redox cofactor, it accepts a hydride at the C4 position of its nicotinamide ring to form NADH — a reversible reaction exploited by hundreds of oxidoreductases and dehydrogenases that bind it through a conserved βαβ Rossmann-fold dinucleotide-binding motif. As a consumable cosubstrate, NAD+ is cleaved at the glycosidic bond between nicotinamide and the ADP-ribose moiety by three signaling-enzyme families: poly(ADP-ribose) polymerases (PARPs/ARTDs), which transfer ADP-ribose units onto acceptor proteins in DNA-damage responses; sirtuins (SIRT1–7), NAD+-dependent protein deacylases that couple acyl-lysine mark removal to production of nicotinamide and 2′-O-acyl-ADP-ribose; and NAD+ glycohydrolases/ADP-ribosyl cyclases (CD38, CD157/BST1, and the TIR-domain NADase SARM1). Cellular NAD+ pools are compartmentalized across the cytosol, nucleus, and mitochondria, with SLC25A51 identified as a mammalian mitochondrial NAD+ transporter.
Storage & Handling
Storage & Handling
Lyophilized
20°C long term
store desiccated, sealed from air, and protected from light. NAD+ is hygroscopic.
Hygroscopic in solid state; aqueous NAD+ is labile and degrades with heat, alkaline pH, and repeated freeze-thaw. Aliquot working solutions to limit hydrolysis.
References
References
Reviews
- 1
Navas LE, Carnero A (2022). Cells
- 2
Covarrubias AJ, Perrone R, Grozio A, Verdin E (2021). Nature Reviews Molecular Cell Biology
Reviews
- 3
Katsyuba E, Romani M, Hofer D, Auwerx J (2020). Nature Metabolism
- 4
Alemasova EE, Lavrik OI (2019). Nucleic Acids Research
- 5
Chini CCS, et al. (2018). Trends in Pharmacological Sciences
- 6
Cantó C, Menzies KJ, Auwerx J (2015). Cell Metabolism
- 7
Houtkooper RH, Cantó C, Wanders RJ, Auwerx J (2010). Endocrine Reviews
Clinical
- 8
Wang DD, et al. (2025). eClinicalMedicine
- 9
et al. (2023). PubMed
- 10
Yoshino M, Yoshino J, et al. (2021). Science
- 11
Martens CR, Denman BA, Mazzo MR, et al. (2018). Nature Communications
- 12
Elhassan YS, et al. (2017). J Endocr Soc
- 13
Trammell SAJ, Schmidt MS, Weidemann BJ, et al. (2016). Nature Communications
Primary research
- 14
Luongo TS, Eller JM, Lu MJ, et al. (2020). Nature
- 15
Girardi E, Agrimi G, Goldmann U, et al. (2020). Nature Communications
- 16
Jiang Y, Liu T, Lee CH, Chang Q, Yang J, Zhang Z (2020). Nature
- 17
Katsyuba E, Mottis A, Zietak M, et al. (2018). Nature
- 18
Essuman K, Summers DW, Sasaki Y, et al. (2017). Neuron
- 19
Camacho-Pereira J, Tarragó MG, Chini CCS, et al. (2016). Cell Metabolism
- 20
Mills KF, Yoshida S, Stein LR, et al. (2016). Cell Metabolism
- 21
Bieganowski P, Brenner C (2004). Cell
- 22
Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000). Nature
Primary Database
Primary Database
Also known as: Nicotinamide adenine dinucleotide, Nadide
View this compound in the Research Library →- Jun 24, 2026Austin J.Verified
qr worked perfect, coa was there and matched, packaging was solid,...
qr worked perfect, coa was there and matched, packaging was solid, shipped quick, no issues with this order
- Jun 10, 2026William S.Verified
Product presentation includes batch-specific third-party COA accessible...
Product presentation includes batch-specific third-party COA accessible via vial QR code. Labeling is clear and corresponds to documentation. Packaging maintains container integrity. Appropriate for research laboratory use.
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
