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For Research Purposes Only
Out of StockPinealon
Third-Party TestedPurity Standards
Total
$39.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Synthetic linear tripeptide (peptide bioregulator)
Molecular formula
C15H26N6O8
Molecular weight
~418.4 g/mol
CAS number
175175-23-2
Amino acids
3
Sequence
Glu-Asp-Arg (EDR); H-L-Glu-L-Asp-L-Arg-OH
Mechanism & Target Class
Mechanism & Target Class
Pinealon carries no assigned cell-surface or cytoplasmic receptor in the literature. The proposed mode of action is receptor-independent: direct interaction with nuclear DNA and possibly histone proteins, positioned as a transcriptional/epigenetic regulator. Biophysical studies (NMR, viscometry, molecular dynamics) characterize contacts at the N7 and O6 atoms of guanine within the DNA major groove, with divalent Mg²⁺ reported to facilitate binding by screening the phosphate backbone. Molecular-docking analyses map candidate binding sites on promoter sequences of genes including TPH1, SOD2, GPX1, CASP3, PPARA, and PPARG. Cellular readouts measured in culture models include reactive-oxygen-species accumulation, MAPK/ERK1/2 phosphorylation kinetics, cell-cycle phase distribution, antioxidant-enzyme expression (SOD2, GPX1), and pro-apoptotic markers (caspase-3, p53).
Storage & Handling
Storage & Handling
Lyophilized
20°C long term
0–4°C short term.
Hygroscopic short peptide; protect from light and moisture.
References
References
Reviews
- 1
Khavinson VKh, et al. (2022). International Journal of Molecular Sciences
- 2
Khavinson VKh, Linkova NS, et al. (2021). Molecules
Reviews
- 3
Khavinson VKh, Linkova NS, Kozhevnikova EO, Trofimova SV. (2021). Molecules
Primary research
- 4
Khavinson VKh, et al. (2021). Pharmaceuticals (Basel)
- 5
Khavinson VKh, et al. (2025). Pharmaceuticals (Basel)
- 6
Karantysh GV, et al. (2020). Neurochemical Journal
- 7
Silanteva IA, et al. (2019). Journal of Physical Chemistry B
- 8
Kraskovskaya NA, et al. (2017). Bulletin of Experimental Biology and Medicine
- 9
Kraskovskaya NA, et al. (2017). Bulletin of Experimental Biology and Medicine
- 10
Khavinson VKh, et al. (2017). Journal of Neurology and Neuroscience
- 11
Khavinson VKh, Lin'kova NS, Tarnovskaya SI. (2016). Bulletin of Experimental Biology and Medicine
- 12
Khavinson VKh, et al. (2015). Advances in Gerontology
- 13
Khavinson VKh, et al. (2014). Advances in Gerontology
- 14
Khavinson VKh, et al. (2014). Bulletin of Experimental Biology and Medicine
- 15
Arutjunyan AV, Kozina LS, Stvolinskiy SL, Bulygina ER, Mashkina AP, Khavinson VKh. (2012). International Journal of Clinical and Experimental Medicine
- 16
Khavinson VKh, et al. (2012). Bulletin of Experimental Biology and Medicine
- 17
Khavinson VKh, et al. (2011). Rejuvenation Research
- 18
Kraskovskaya NA, et al. (2024). Int J Mol Sci
- 19
Sakhenberg EI, et al. (2025). Curr Issues Mol Biol
- 20
Voicekhovskaya MA, et al. (2012). Bull Exp Biol Med
- 21
Khavinson VKh, et al. (2011). Bull Exp Biol Med
- 22
Mendzheritskii AM, et al. (2011). Adv Gerontol
Primary Database
Primary Database
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
