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For Research Purposes Only
Out of StockTB Fragment
Third-Party TestedPurity Standards
Total
$34.99Size
Quantity
1
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Molecular Profile
Molecular Profile
Type
Synthetic peptide (Thymosin Beta-4 actin-binding fragment)
Molecular formula
C38H68N10O14
Molecular weight
~889.0 g/mol
CAS number
885340-08-9
Amino acids
7
Sequence
Ac-LKKTETQ
Modification
N-terminal acetylation (Ac-LKKTETQ). This is the SHORT actin-binding fragment — residues 17-23 of Thymosin Beta-4 — and is a chemically distinct molecule from full-length Tβ4 (43 residues; CAS 77591-33-4). The two are studied as separate species: the fragment is the central actin-binding motif, while the great majority of published in vivo and clinical research has examined the full-length peptide.
Mechanism & Target Class
Mechanism & Target Class
The LKKTET(Q) motif is the central actin-binding domain of Thymosin Beta-4, the principal intracellular G-actin-sequestering peptide. Biochemical and structural research characterizes this segment as a primary contact site that engages monomeric (G-)actin and modulates actin polymerization; it acts through actin binding rather than through a defined cell-surface receptor.
Storage & Handling
Storage & Handling
Lyophilized
20°C
~24 months desiccated and protected from light.
Highly water-soluble; protect from light; aliquot to avoid freeze-thaw; salt form affects exact mass.
References
References
Reviews
- 1
Mannherz HG, Hannappel E. (2009). Cell Motil Cytoskeleton
- 2
Goldstein AL, et al. (2012). Expert Opin Biol Ther
Reviews
- 3
Hannappel E. (2007). Ann NY Acad Sci
- 4
Goldstein AL, et al. (2005). Trends Mol Med
Primary research
- 5
Xue B, et al. (2014). Proc Natl Acad Sci USA
- 6
Esposito S, et al. (2012). Drug Test Anal
- 7
Ho ENM, et al. (2012). J Chromatogr A
- 8
Didry D, et al. (2012). EMBO J
- 9
Dettin M, et al. (2011). Cell Immunol
- 10
Wyczółkowska J, et al. (2007). Peptides
- 11
Irobi E, et al. (2004). EMBO J
- 12
Hertzog M, et al. (2004). Cell
- 13
Philp D, et al. (2003). FASEB J
- 14
Simenel C, et al. (2000). Eur J Biochem
- 15
Van Troys M, et al. (1996). EMBO J
- 16
Hannappel E, Wartenberg F. (1993). Biol Chem Hoppe-Seyler
- 17
Weber A, et al. (1992). Biochemistry
- 18
Safer D, Elzinga M, Nachmias VT. (1991). J Biol Chem
Primary Database
Primary Database
Also known as: Thymosin β4 actin-binding fragment, Ac-LKKTETQ, LKKTETQ, Tβ4(17-23), Thymosin beta-4 fragment 17-23
View this compound in the Research Library →Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
