ACE-031
A soluble ActRIIB-Fc fusion protein studied in preclinical muscle and cellular signaling research models.
Quick answers
What is ACE-031?
ACE-031 is a recombinant Fc-fusion protein (ActRIIB extracellular domain - human IgG1 Fc; disulfide-linked homodimer) of 343 amino acids with a molecular weight of ~58.4 kDa per monomer (glycosylated).
How much published research cites ACE-031?
The Luvaminos ACE-031 record cites 19 published references, dated 2001 to 2025. Each is listed on this page with a link to its source.
Does Luvaminos test ACE-031, and where is the certificate?
Luvaminos does not currently stock ACE-031. Every peptide lot Luvaminos sells is tested by Freedom Diagnostics Testing, PLLC, an independent laboratory, and its certificate is published at luvaminos.com/coa under the lot number printed on the vial.
What modifications does ACE-031 carry?
ACE-031: Disulfide-linked homodimer. Each 343-residue chain comprises the ACVR2B extracellular domain (residues 1-115), a triglycyl linker (116-118), and a human IgG1 Fc (119-343); seven intrachain disulfide bridges per chain, two interchain disulfide bridges joining the two chains, and three N-glycosylation sites per chain.
How is ACE-031 powder stored?
Sealed ACE-031 powder: -20C (-80C long term); supplied lyophilized. Lyophilized powder is stable when kept sealed and dry. Protect from light; confirm handling against the specific lot Certificate of Analysis.
Molecular Profile
- Type
- Recombinant Fc-fusion protein (ActRIIB extracellular domain - human IgG1 Fc; disulfide-linked homodimer)
- Molecular weight
- ~58.4 kDa per monomer (glycosylated)
- CAS number
- 1169766-01-1
- Amino acids
- 343
- Modification
- Disulfide-linked homodimer. Each 343-residue chain comprises the ACVR2B extracellular domain (residues 1-115), a triglycyl linker (116-118), and a human IgG1 Fc (119-343); seven intrachain disulfide bridges per chain, two interchain disulfide bridges joining the two chains, and three N-glycosylation sites per chain.
Mechanism & Target Class
A soluble decoy receptor. The extracellular ACVR2B domain binds circulating TGF-beta superfamily ligands - myostatin (GDF-8), activin A, activin B, and GDF-11 - so that they do not engage membrane-bound type II activin receptors and recruit type I receptors (ALK4/ALK5), modulating SMAD2/3 signaling in the activin-receptor pathway in skeletal muscle. The construct also binds the vascular regulators BMP-9/BMP-10, with comparatively lower affinity for BMP-2/BMP-7. The IgG1 Fc drives dimerization and confers extended circulation.
Storage & Handling
- Lyophilized
- -20C (-80C long term); supplied lyophilized. Lyophilized powder is stable when kept sealed and dry.
- Handling
- protect from light; confirm handling against the specific lot Certificate of Analysis.
Primary Database
References (19)
Reviews
1Lee SJ. (2023). Annual Review of Physiology
- 2
Rybalka E, et al. (2020). Cells
- 3
Suh J, Lee YS. (2020). Journal of Bone Metabolism
Clinical
4Campbell C, et al. (2017). Muscle & Nerve
- 5
Attie KM, et al. (2013). Muscle & Nerve
- 6
ClinicalTrials.gov (A031-01). ClinicalTrials.gov
- 7
ClinicalTrials.gov (A031-02). ClinicalTrials.gov
- 8
ClinicalTrials.gov (A031-03). ClinicalTrials.gov
- 9
ClinicalTrials.gov (A031-06). ClinicalTrials.gov
Primary research
10Reichel C, et al. (2025). Drug Testing and Analysis
- 11
Lach-Trifilieff E, et al. (2014). Molecular and Cellular Biology
- 12
Pistilli EE, et al. (2011). American Journal of Pathology
- 13
Cadena SM, et al. (2010). Journal of Applied Physiology
- 14
Sako D, et al. (2010). Journal of Biological Chemistry
- 15
Zhou X, et al. (2010). Cell
- 16
Koncarevic A, et al. (2010). Endocrinology
- 17
Pistilli EE, et al. (2010). American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
- 18
Lee SJ, et al. (2005). Proceedings of the National Academy of Sciences
- 19
Lee SJ, McPherron AC. (2001). Proceedings of the National Academy of Sciences
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