Luvaminos

Adipotide

A synthetic 26-residue peptidomimetic conjugate of a cysteine-flanked homing nonapeptide and a D-amino acid amphipathic heptapeptide repeat domain.

Quick answers

What is Adipotide?

Adipotide is a synthetic 26-residue peptidomimetic conjugate of a cysteine-flanked homing nonapeptide and a D-amino acid amphipathic heptapeptide repeat domain. It is a synthetic peptide (peptidomimetic) of 26 amino acids with a molecular weight of 2557.2 g/mol and the formula C₁₁₁H₂₀₆N₃₆O₂₈S₂.

How much published research cites Adipotide?

The Luvaminos Adipotide record cites 20 published references, dated 2002 to 2022. Each is listed on this page with a link to its source.

Does Luvaminos test Adipotide, and where is the certificate?

Luvaminos does not currently stock Adipotide. Every peptide lot Luvaminos sells is tested by Freedom Diagnostics Testing, PLLC, an independent laboratory, and its certificate is published at luvaminos.com/coa under the lot number printed on the vial.

What modifications does Adipotide carry?

Adipotide: Contains two D-enantiomeric (D-amino acid) heptapeptide repeats forming an amphipathic proapoptotic domain; cysteine residues present in the homing motif; linear conjugate connected by a GG linker.

How is Adipotide powder stored?

Sealed Adipotide powder: Store dry at −20 °C or below, protected from moisture and light. Protect from light and heat.

Molecular Profile

Type
Synthetic peptide (peptidomimetic)
Molecular formula
C₁₁₁H₂₀₆N₃₆O₂₈S₂
Molecular weight
2557.2 g/mol
CAS number
859216-15-2
Amino acids
26
Sequence
CKGGRAKDC-GG-D(KLAKLAK)₂
Modification
Contains two D-enantiomeric (D-amino acid) heptapeptide repeats forming an amphipathic proapoptotic domain; cysteine residues present in the homing motif; linear conjugate connected by a GG linker.

Mechanism & Target Class

Adipotide is a two-module synthetic peptidomimetic conjugate. The N-terminal CKGGRAKDC homing segment is a cysteine-flanked nonapeptide whose paired cysteine residues constrain the loop conformation. A GG dipeptide linker connects it to the C-terminal D(KLAKLAK)₂ domain, a tandem heptapeptide repeat built entirely from D-enantiomeric amino acids that folds into an amphipathic α-helix. Structural studies of the conjugate have characterized the sequence alignment of the CKGGRAKDC motif and the membrane-associating behavior of the amphipathic helical domain in vitro.

Storage & Handling

Lyophilized
Store dry at −20 °C or below, protected from moisture and light.
Handling
protect from light and heat.

Primary Database

PubChem CID 163360068 ↗

References (20)

  1. Reviews

    1

    Daquinag A.C., Zhang Y., Kolonin M.G. (2011). Trends Pharmacol Sci

    DOI: 10.1016/j.tips.2011.01.004PubMed 21349592

  2. 2

    Ande S.R., Nguyen K.H., Nyomba B.L.G., Mishra S. (2016). Trends Endocrinol Metab

    DOI: 10.1016/j.tem.2016.05.003PubMed 27312736

  3. 3

    Sibuyi N.R.S., Meyer M., Onani M.O., Skepu A., Madiehe A.M. (2018). Int J Nanomedicine

    DOI: 10.2147/IJN.S173424PubMed 30538468

  4. 4

    Xu Y.X.Z., Bassi G., Mishra S. (2019). Biol Sex Differ

    DOI: 10.1186/s13293-019-0239-5PubMed 31118075

  5. 5

    Fang Y., Kaszuba T., Imoukhuede P.I. (2020). Front Physiol

    DOI: 10.3389/fphys.2020.00831PubMed 32760294

  6. 6

    Cao Y. (2010). Nat Rev Drug Discov

    DOI: 10.1038/nrd3055PubMed 20118961

  7. Clinical

    7

    ClinicalTrials.gov (2012). ClinicalTrials.gov

    NCT01262664

  8. Primary research

    8

    Salameh A., Daquinag A.C., Staquicini D.I., An Z., Hajjar K.A., Pasqualini R., Arap W., Kolonin M.G. (2016). JCI Insight

    DOI: 10.1172/jci.insight.86351PubMed 27468426

  9. 9

    Staquicini F.I., Cardó-Vila M., Kolonin M.G., Treplev M., et al. (2011). PNAS

    DOI: 10.1073/pnas.1114503108PubMed 22049339

  10. 10

    Barnhart K.F., Christianson D.R., Wetterau L., Erickson J.A., et al. (2011). Sci Transl Med

    DOI: 10.1126/scitranslmed.3002621PubMed 22072637

  11. 11

    Kim D.-H., Woods S.C., Seeley R.J. (2010). Diabetes

    DOI: 10.2337/db09-1141PubMed 20103704

  12. 12

    Kolonin M.G., Saha P.K., Chan L., Pasqualini R., Arap W. (2004). Nat Med

    DOI: 10.1038/nm1048PubMed 15133506

  13. 13

    Kim D.-H., Sartor M.A., Bain J.R., Sandoval D., et al. (2012). Diabetes

    DOI: 10.2337/db11-1579PubMed 22733798

  14. 14

    Daquinag A.C., Tseng C., Salameh A., Zhang Y., et al. (2015). Cell Death Differ

    DOI: 10.1038/cdd.2014.148PubMed 25342467

  15. 15

    Daquinag A.C., Tseng C., Zhang Y., Amaya-Manzanares F., et al. (2016). Mol Ther

    DOI: 10.1038/mt.2015.155PubMed 26316391

  16. 16

    Gao Z., Daquinag A.C., Yu Y., Kolonin M.G. (2022). Diabetes

    DOI: 10.2337/db21-0972

  17. 17

    Hossen M.N., Kajimoto K., Akita H., Hyodo M., Harashima H. (2012). J Control Release

    DOI: 10.1016/j.jconrel.2012.09.002PubMed 22982237

  18. 18

    Bacher S., Achatz G., Schmitz M.L., Lamers M.C. (2002). Biochimie

    DOI: 10.1016/S0300-9084(02)00027-5PubMed 12628297

  19. 19

    Bahmani T., Sharifzadeh S., Tamaddon G., et al. (2021). J Biomed Phys Eng

    DOI: 10.31661/jbpe.v0i0.905PubMed 33937129

  20. 20

    Su F., Ahn S., Saha A., DiGiovanni J., Kolonin M.G. (2019). Oncogene

    DOI: 10.1038/s41388-018-0558-8PubMed 30361686

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About Adipotide

What is Adipotide?

Adipotide is a synthetic 26-residue peptidomimetic conjugate of a cysteine-flanked homing nonapeptide and a D-amino acid amphipathic heptapeptide repeat domain.

What are the molecular formula, molecular weight and CAS number of Adipotide?

Adipotide: molecular formula C₁₁₁H₂₀₆N₃₆O₂₈S₂, molecular weight 2557.2 g/mol and CAS number 859216-15-2.

What is the sequence of Adipotide?

CKGGRAKDC-GG-D(KLAKLAK)₂.

How is Adipotide powder stored?

Store dry at −20 °C or below, protected from moisture and light.