ARA-290 (cibinetide)

A synthetic 11-amino-acid erythropoietin helix-B-derived peptide studied as a selective ligand of the innate repair receptor (EPOR/CD131 heterocomplex).

Molecular Profile

Type
Synthetic linear 11-amino-acid non-erythropoietic helix-B surface peptide
Molecular formula
C51H84N16O21
Molecular weight
~1,257.3 g/mol
CAS number
1208243-50-8
Amino acids
11
Sequence
pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
Modification
N-terminal pyroglutamate (pGlu)

Mechanism & Target Class

ARA-290 is a synthetic peptide derived from the three-dimensional helix-B surface region of erythropoietin (EPO). EPO biology involves two functionally distinct receptor configurations: a homodimeric EPOR/EPOR complex mediating erythropoiesis in erythroid progenitor cells, and a heteromeric EPOR/CD131 (beta-common receptor, βcR) complex — termed the innate repair receptor (IRR) or tissue-protective receptor — that shares the CD131 signaling subunit with the GM-CSF, IL-3, and IL-5 receptors. The foundational EPOR/CD131 heterocomplex characterization was reported by Brines et al. (2004); short tissue-protective helix-B peptide sequences, including the 11-amino-acid precursor of ARA-290, were delimited by Brines et al. (2008). In preclinical cellular systems, IRR engagement is associated with downstream JAK2/STAT3, PI3K/Akt, and ERK pathway activation and with anti-apoptotic transcriptional responses. Mechanistic literature describes IRR expression as locally upregulated in injured, hypoxic, or inflamed tissue rather than constitutively expressed at high levels. ARA-290 has also been reported to interact with TRPV1 channel activity in nociception model systems (Zhang et al., 2016), proposing a direct nociceptor mechanism alongside IRR-mediated anti-inflammatory signaling.

Storage & Handling

Lyophilized
Lyophilized powder: −20°C or below; −80°C recommended for long-term archival.
Handling
Water-soluble. Avoid repeated freeze-thaw cycles. For research use only.

Primary Database

PubChem CID 91810664 ↗

References (27)

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