GHRP-2

A synthetic, C-terminally amidated hexapeptide built from non-natural D-amino acids and a 2-naphthylalanine residue, characterized in structural and receptor-binding studies of a class A G protein-coupled receptor.

Molecular Profile

Type
Synthetic peptide (hexapeptide)
Molecular formula
C45H55N9O6
Molecular weight
817.97 g/mol
CAS number
158861-67-7
Amino acids
6
Sequence
D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
Modification
N-terminal D-Ala; D-2-naphthylalanine; D-Phe; C-terminal amide.

Mechanism & Target Class

A synthetic, C-terminally amidated hexapeptide built from non-natural D-amino acids and a 2-naphthylalanine residue at position 2 — structural features studied for their contribution to enzymatic stability and receptor-binding interaction. It binds within the orthosteric pocket of a class A G protein-coupled receptor; that pocket has been resolved in cryo-EM structures of the receptor bound to its endogenous peptide ligand together with related synthetic peptide and non-peptide ligands, defining the shared binding-pocket geometry relevant to this peptide class. Pharmacokinetic characterization describes a small, unmodified peptide subject to enzymatic and aqueous degradation with a short reported plasma half-life.

Storage & Handling

Lyophilized
-20°C; typically stable 24-36 months desiccated.
Handling
Avoid freeze-thaw; aliquot; protect from light and moisture.

Primary Database

PubChem CID 6852372 ↗

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