GHRP-6

A synthetic, C-terminally amidated hexapeptide incorporating two D-amino-acid substitutions, studied as a tool compound in class A GPCR structural pharmacology.

Molecular Profile

Type
Synthetic peptide (hexapeptide)
Molecular formula
C46H56N12O6
Molecular weight
873.0 g/mol
CAS number
87616-84-0
Amino acids
6
Sequence
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Modification
D-Trp and D-Phe; C-terminal amide.

Mechanism & Target Class

A synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, bearing a C-terminal amide and two D-amino-acid substitutions (D-Trp at position 2, D-Phe at position 5) that confer protease resistance to the L-amino-acid backbone. In structural-pharmacology studies it serves as a tool ligand for a class A GPCR, where the compact six-residue scaffold defines a distinct binding pose within the receptor's orthosteric pocket.

Storage & Handling

Lyophilized
-20°C; typically stable 24-36 months desiccated.
Handling
Avoid freeze-thaw; aliquot; protect from light and moisture.

Primary Database

PubChem CID 5486806 ↗

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