Luvaminos

MGF

A mechanically induced IGF-1 splice-variant peptide studied in preclinical muscle and cellular research models.

Quick answers

What is MGF?

MGF is a synthetic peptide (IGF-1Ec C-terminal E-domain, 24 residues) with a molecular weight of ~2,868 g/mol and the formula C121H199N41O40.

How much published research cites MGF?

The Luvaminos MGF record cites 25 published references, dated 1996 to 2022. Each is listed on this page with a link to its source.

Does Luvaminos test MGF, and where is the certificate?

Luvaminos does not currently stock MGF. Every peptide lot Luvaminos sells is tested by Freedom Diagnostics Testing, PLLC, an independent laboratory, and its certificate is published at luvaminos.com/coa under the lot number printed on the vial.

What modifications does MGF carry?

MGF: The synthetic research peptide corresponds to the free-acid 24-residue E-domain.

How is MGF powder stored?

Sealed MGF powder: -20°C (colder for long-term); keep desiccated and frozen until use. Minimize freeze-thaw cycles; protect from light.

How is MGF different from PEG-MGF?

MGF and PEG-MGF are different compounds: MGF has 24 amino acids, a molecular weight of ~2,868 g/mol and formula C121H199N41O40; PEG-MGF has 24 amino acids and a molecular weight of ~2.7 kDa (unPEGylated peptide portion; approximate). MGF: The synthetic research peptide corresponds to the free-acid 24-residue E-domain.

Molecular Profile

Type
Synthetic peptide (IGF-1Ec C-terminal E-domain, 24 residues)
Molecular formula
C121H199N41O40
Molecular weight
~2,868 g/mol
Amino acids
24
Sequence
YQPPSTNKNTKSQRRKGSTFEEHK
Modification
The synthetic research peptide corresponds to the free-acid 24-residue E-domain; stabilized analogs substitute D-arginine in the central basic (QRRK) region and amidate the C-terminus to slow proteolysis, and PEGylated forms (PEG-MGF) couple a polyethylene glycol chain to extend circulating half-life.

Mechanism & Target Class

MGF is a synthetic peptide corresponding to the unique C-terminal E-domain of a mechanically inducible IGF-1 splice isoform, a structure generated when inclusion of a short exon-5 insert shifts the reading frame in exon 6 to produce a 24-residue sequence distinct from the predominant systemic isoform. A central, unresolved structural question in the literature is which receptor, if any, this E-domain peptide engages; no dedicated E-peptide binding partner has been definitively identified. The peptide's arginine/lysine-rich polybasic motif has been studied as a potential cell-penetrating and nuclear-localization element, and specific protein interactions (e.g., with 14-3-3 proteins in cardiac cell models) have been characterized.

Storage & Handling

Lyophilized
-20°C (colder for long-term); keep desiccated and frozen until use.
Handling
Minimize freeze-thaw cycles; protect from light.

Primary Database

PubChem CID 175675731 ↗

References (25)

  1. Reviews

    1

    Vassilakos G, et al. (2014). Hormones (Athens)

    DOI: 10.1007/BF03401333

  2. 2

    Brisson BK, Barton ER. (2013). Frontiers in Endocrinology

    DOI: 10.3389/fendo.2013.00042

  3. 3

    Matheny RW Jr, Nindl BC, Adamo ML. (2010). Endocrinology

    DOI: 10.1210/en.2009-1217PubMed 20130113

  4. 4

    Goldspink G. (2005). Physiology (Bethesda)

    DOI: 10.1152/physiol.00004.2005

  5. Clinical

    5

    Hameed M, et al. (2004). Journal of Physiology

    DOI: 10.1113/jphysiol.2003.051722PubMed 14565994

  6. 6

    Hameed M, et al. (2003). Journal of Physiology

    DOI: 10.1113/jphysiol.2002.032136PubMed 12562960

  7. Primary research

    7

    Solís C, et al. (2022). Frontiers in Physiology

    DOI: 10.3389/fphys.2022.1028345PubMed 36467694

  8. 8

    Armakolas A, et al. (2015). Molecular Medicine

    DOI: 10.2119/molmed.2014.00222PubMed 25569803

  9. 9

    Fornaro M, et al. (2014). American Journal of Physiology-Endocrinology and Metabolism

    DOI: 10.1152/ajpendo.00408.2013

  10. 10

    Mavrommatis E, Shioura KM, Los T, Goldspink PH. (2013). Molecular and Cellular Biochemistry

    DOI: 10.1007/s11010-013-1689-4PubMed 23712705

  11. 11

    Schlegel W, et al. (2013). PLOS ONE

    DOI: 10.1371/journal.pone.0076133

  12. 12

    Brisson BK, Barton ER. (2012). PLOS ONE

    DOI: 10.1371/journal.pone.0045588

  13. 13

    Deng M, et al. (2011). International Orthopaedics

    DOI: 10.1007/s00264-010-1141-2PubMed 21057789

  14. 14

    Kandalla PK, Goldspink G, Butler-Browne G, Mouly V. (2011). Mechanisms of Ageing and Development

    DOI: 10.1016/j.mad.2011.02.007PubMed 21354439

  15. 15

    Armakolas A, et al. (2010). The Prostate

    DOI: 10.1002/pros.21158PubMed 20564425

  16. 16

    Stavropoulou A, et al. (2009). Molecular Medicine

    DOI: 10.2119/molmed.2009.00012

  17. 17

    Riddoch-Contreras J, et al. (2009). Experimental Neurology

    DOI: 10.1016/j.expneurol.2008.10.014

  18. 18

    Philippou A, et al. (2008). In Vivo

    PubMed 18396778

  19. 19

    Carpenter V, et al. (2008). Heart, Lung and Circulation

    DOI: 10.1016/j.hlc.2007.04.013PubMed 17581790

  20. 20

    Ates K, et al. (2007). FEBS Letters

    DOI: 10.1016/j.febslet.2007.05.030PubMed 17531227

  21. 21

    Dłużniewska J, et al. (2005). FASEB Journal

    DOI: 10.1096/fj.05-3786fjePubMed 16144956

  22. 22

    Aperghis M, et al. (2004). Brain Research

    DOI: 10.1016/j.brainres.2004.02.061

  23. 23

    Yang SY, Goldspink G. (2002). FEBS Letters

    DOI: 10.1016/s0014-5793(02)02918-6PubMed 12095637

  24. 24

    McKoy G, et al. (1999). Journal of Physiology

    DOI: 10.1111/j.1469-7793.1999.0583v.xPubMed 10087355

  25. 25

    Yang S, Alnaqeeb M, Simpson H, Goldspink G. (1996). Journal of Muscle Research and Cell Motility

    DOI: 10.1007/BF00123364PubMed 8884603

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About MGF

What is MGF?

MGF is a mechanically induced IGF-1 splice-variant peptide studied in preclinical muscle and cellular research models.

What are the molecular formula and molecular weight of MGF?

MGF: molecular formula C121H199N41O40 and molecular weight ~2,868 g/mol.

What is the sequence of MGF?

YQPPSTNKNTKSQRRKGSTFEEHK.

How is MGF powder stored?

-20°C (colder for long-term); keep desiccated and frozen until use.