SNAP-8

An acetylated octapeptide investigated as a SNARE-complex / SNAP-25 mimetic in cosmetic-science and neuroexocytosis mechanistic research.

Molecular Profile

Type
Synthetic octapeptide (8 amino acids)
Molecular formula
C42H72N16O15S
Molecular weight
1073.2 g/mol
CAS number
868844-74-0
Amino acids
8
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Modification
N-terminal acetylation and C-terminal amidation (reduces amino- and carboxypeptidase susceptibility); two-residue Ala-Asp extension of the parent six-residue Acetyl Hexapeptide-8 scaffold.

Mechanism & Target Class

SNAP-8 is designed to mimic the N-terminal region of SNAP-25, a component of the ternary SNARE complex (SNAP-25 / syntaxin / VAMP-synaptobrevin) that drives Ca²⁺-dependent synaptic vesicle fusion and neurotransmitter exocytosis. By competing with native SNAP-25 for incorporation into SNARE complex formation, the peptide is proposed to modulate vesicle docking and neurotransmitter release — a mechanism of competitive interference at the protein-assembly level, distinct from proteolytic cleavage mechanisms. The two-residue extension over the parent hexapeptide covers a larger portion of the SNAP-25 N-terminal helical segment, which structural studies identify as critical for SNARE complex assembly. Computational work additionally implicates synaptotagmin-1 (the Ca²⁺ sensor for exocytosis) as a potential secondary interaction site for this peptide class.

Storage & Handling

Lyophilized
-20°C, sealed, protected from light and moisture; ~24 months.
Handling
Methionine residue is oxidation-sensitive — protect from light and oxygen; avoid freeze-thaw cycles; keep sealed.

Primary Database

PubChem CID 71587832 ↗

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