TB Fragment

The actin-binding fragment of Thymosin Beta-4, studied in preclinical cellular research models.

Molecular Profile

Type
Synthetic peptide (Thymosin Beta-4 actin-binding fragment)
Molecular formula
C38H68N10O14
Molecular weight
~889.0 g/mol
CAS number
885340-08-9
Amino acids
7
Sequence
Ac-LKKTETQ
Modification
N-terminal acetylation (Ac-LKKTETQ). This is the SHORT actin-binding fragment — residues 17-23 of Thymosin Beta-4 — and is a chemically distinct molecule from full-length Tβ4 (43 residues; CAS 77591-33-4). The two are studied as separate species: the fragment is the central actin-binding motif, while the great majority of published in vivo and clinical research has examined the full-length peptide.

Mechanism & Target Class

The LKKTET(Q) motif is the central actin-binding domain of Thymosin Beta-4, the principal intracellular G-actin-sequestering peptide. Biochemical and structural research characterizes this segment as a primary contact site that engages monomeric (G-)actin and modulates actin polymerization; it acts through actin binding rather than through a defined cell-surface receptor.

Storage & Handling

Lyophilized
-20°C; ~24 months desiccated and protected from light.
Handling
Highly water-soluble; protect from light; aliquot to avoid freeze-thaw; salt form affects exact mass.

Primary Database

PubChem CID 62707662 ↗

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