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Cognitive
A synthetic 9-residue peptide built on the ACTH(4–10) fragment scaffold with an adamantyl modification, studied in preclinical neuroscience research.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Type
Synthetic peptide (ACTH fragment analog, 9 residues)
Molecular formula
C50H69N11O11S
Molecular weight
1032.23 g/mol
Amino acids
9
Sequence
Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly-NH₂
Modification
N-terminal acetylation; C-terminal amidation; C-terminal adamantylglycine residue (adamantane cage moiety).
A synthetic peptide corresponding to the ACTH(4–10) fragment scaffold, sharing the core Met-Glu-His-Phe-Pro-Gly-Pro sequence of Semax and extending it with Ala-Gly at the C-terminus. The terminal residue carries an adamantyl moiety — a rigid lipophilic cage incorporated in related peptide analogs to investigate how hydrophobic substitutions affect membrane penetration and proteolytic stability. N-terminal acetylation and C-terminal amidation cap the sequence, structural modifications studied for their effect on conformational stability and resistance to enzymatic degradation in tissue-preparation assays.
Lyophilized
Store refrigerated or at −20 °C, protected from light
use desiccant as needed.
Avoid repeated freeze-thaw cycles; protect from light and microbial contamination; prepare fresh aliquots for each experiment.
Reviews
Markov DD, Dolotov OV, Grivennikov IA (2023). Int. J. Mol. Sci.
Primary research
Radchenko AI, Sobolevsky OI, et al. (2025). Acta Naturae
Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F (2022). ACS Chem. Neurosci.
Primary research
Sudarkina OY, Remizova JA, et al. (2021). Int. J. Mol. Sci.
Dolotov OV, Karpenko EA, Seredenina TS, et al. (2006). J. Neurochem.
Medvedeva EM, Dergunova LV, Filippenkov IB, et al. (2014). BMC Genomics
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. (2006). Brain Res.
Shadrina MI, Dolotov OV, Grivennikov IA, et al. (2001). Neurosci. Lett.
Agapova TY, Agniullin YV, Shadrina MI, et al. (2007). Neurosci. Lett.
Shadrina M, Kolomin T, Agapova T, et al. (2009). J. Mol. Neurosci.
Storozhevykh TP, Tukhbatova GR, Senilova YE, et al. (2007). Bull. Exp. Biol. Med.
Grivennikov IA, Dolotov OV, Zolotarev YA, et al. (2008). Restor. Neurol. Neurosci.
Eremin KO, Kudrin VS, Saransaari P, et al. (2005). Neurochem. Res.
Bashkatova VG, Koshelev VB, Fadyukova OE, et al. (2001). Brain Res.
Dmitrieva VG, Kolomin TA, Shadrina MI, et al. (2009). Cell Mol. Neurobiol.
Medvedeva EV, Dmitrieva VG, Limborska SA, et al. (2017). Mol. Genet. Genomics
Filippenkov IB, Stavchansky VV, Denisova AE, et al. (2020). Genes
Dergunova LV, Filippenkov IB, Stavchansky VV, et al. (2021). Mol. Biol.
Stavchansky VV, Yuzhakov VV, Sevan'kaeva LE, et al. (2024). Curr. Issues Mol. Biol.
Filippenkov IB, Shpetko YY, Stavchansky VV, et al. (2024). Biomedicines
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
| Compound | Type | Molecular weight | CAS number |
|---|---|---|---|
| ACTH(4–10) Adamantyl AnalogThis page | Synthetic peptide (ACTH fragment analog, 9 residues) | 1032.23 g/mol | — |
| Semax | Synthetic peptide (heptapeptide) | 813.93 g/mol | 80714-61-0 |
| Selank | Synthetic heptapeptide (tuftsin analog) | 751.88 g/mol | 129954-34-3 |
| N-Acetyl Semax | Synthetic linear heptapeptide derivative (N-terminal acetylation, C-terminal amidation); structural analog of ACTH(4–10) | 855.0 g/mol | 2920938-90-3 |
| Pinealon | Synthetic linear tripeptide (peptide bioregulator) | ~418.4 g/mol | 175175-23-2 |
Comparison of laboratory reference specifications only. For research use only; not a therapeutic comparison.
Quality & methods