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Cognitive
An N-terminally acetylated, C-terminally amidated synthetic heptapeptide analog of Semax, retaining the ACTH(4–7) core sequence with a Pro-Gly-Pro C-terminal extension.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Type
Synthetic linear heptapeptide derivative (N-terminal acetylation, C-terminal amidation); structural analog of ACTH(4–10)
Molecular formula
C39H54N10O10S
Molecular weight
855.0 g/mol
CAS number
2920938-90-3
Amino acids
7
Sequence
Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂ (acetyl-MEHFPGP-amide)
Modification
N-terminal acetylation and C-terminal amidation of the parent Semax heptapeptide (CAS 80714-61-0); these terminal modifications are the defining structural difference from the parent.
N-Acetyl Semax retains the ACTH(4–7) core sequence (Met-Glu-His-Phe) of the parent Semax heptapeptide. The Pro-Gly-Pro C-terminal extension found in the parent confers resistance to carboxypeptidase cleavage. The additional N-terminal acetyl group and C-terminal amide are structural modifications studied for resistance to terminal exopeptidase attack (Shevchenko et al., 2013). Structural chemistry work (Magrì et al., 2016) characterized how N-terminal acetylation alters the copper(II) and zinc(II) coordination geometry of the peptide and examined associated in-vitro properties. Studies of the parent compound used tritium-labeled peptide to characterize specific, reversible, calcium-dependent binding sites in rat basal forebrain membranes. The histidine-containing sequence coordinates Cu(II) and Zn(II) ions, situating it in bioinorganic research contexts.
Lyophilized
20°C, protected from light and moisture
stable long term as lyophilized powder.
N-terminal acetylation and C-terminal amidation are structural features studied for resistance to terminal exopeptidase cleavage relative to the parent peptide. As with other methionine-containing peptides, protect from oxidizing conditions and avoid repeated freeze-thaw cycles.
Reviews
Dergunova LV, Filippenkov IB, Limborska SA, Myasoedov NF (2023). Genes (Basel)
Clinical
Gusev EI, Martynov MYu, Kostenko EV, Petrova LV, Bobyreva SN (2018). Zh Nevrol Psikhiatr Im SS Korsakova
Primary research
Liu R, Chen Y, Huang H, et al. (2025). British Journal of Pharmacology
Primary research
Tomasello MF, Di Rosa MC, Naletova I, et al. (2025). Bioinorganic Chemistry and Applications
Radchenko AI, Kuzubova EV, Apostol AA, et al. (2025). Acta Naturae
Inozemtseva LS, Yatsenko KA, Glazova NYu, et al. (2024). European Journal of Pharmacology
Sciacca MFM, et al. (2022). ACS Chemical Neuroscience
Dergunova LV, Dmitrieva VG, Filippenkov IB, et al. (2021). Molecular Biology (Moscow)
Sudarkina OY, Filippenkov IB, Stavchansky VV, et al. (2021). International Journal of Molecular Sciences
Filippenkov IB, Stavchansky VV, Denisova AE, et al. (2020). Genes (Basel)
Medvedeva EV, Dmitrieva VG, Limborska SA, Myasoedov NF, Dergunova LV (2017). Molecular Genetics and Genomics
Magrì A, Tabbì G, Giuffrida A, et al. (2016). Journal of Inorganic Biochemistry
Medvedeva EV, Dmitrieva VG, Povarova OV, et al. (2014). BMC Genomics
Shevchenko KV, Nagaev IY, Andreeva LA, Shevchenko VP, Myasoedov NF (2013). Doklady Biological Sciences
Shadrina M, Kolomin T, Agapova T, et al. (2010). Journal of Molecular Neuroscience
Dmitrieva VG, Povarova OV, Skvortsova VI, Limborska SA, Myasoedov NF, Dergunova LV (2010). Cellular and Molecular Neurobiology
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. (2006). Brain Research
Dolotov OV, Karpenko EA, Seredenina TS, et al. (2006). Journal of Neurochemistry
Eremin KO, Kudrin VS, Saransaari P, et al. (2005). Neurochemical Research
Shadrina MI, Dolotov OV, Grivennikov IA, et al. (2001). Neuroscience Letters
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
| Compound | Type | Molecular weight | CAS number |
|---|---|---|---|
| N-Acetyl SemaxThis page | Synthetic linear heptapeptide derivative (N-terminal acetylation, C-terminal amidation); structural analog of ACTH(4–10) | 855.0 g/mol | 2920938-90-3 |
| Semax | Synthetic peptide (heptapeptide) | 813.93 g/mol | 80714-61-0 |
| Selank | Synthetic heptapeptide (tuftsin analog) | 751.88 g/mol | 129954-34-3 |
| ACTH(4–10) Adamantyl Analog | Synthetic peptide (ACTH fragment analog, 9 residues) | 1032.23 g/mol | — |
| Pinealon | Synthetic linear tripeptide (peptide bioregulator) | ~418.4 g/mol | 175175-23-2 |
Comparison of laboratory reference specifications only. For research use only; not a therapeutic comparison.
Quality & methods