Cognitive
A peptide investigated in preclinical cognitive research.
Selank is studied in research on stress, anxiety, and the immune system. It is a stabilized version of a natural peptide called tuftsin, and in preclinical models researchers look at how it interacts with the brain's calming GABA and serotonin systems as well as with immune-signaling molecules such as cytokines and interferons.
Type
Synthetic peptide (heptapeptide)
Molecular formula
C33H57N11O9
Molecular weight
751.88 g/mol
CAS number
129954-34-3
Amino acids
7
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
Modification
Free termini; tuftsin (Thr-Lys-Pro-Arg) extended with a C-terminal Pro-Gly-Pro motif.
A linear heptapeptide analogue of the immunomodulatory tetrapeptide tuftsin, extended with a Pro-Gly-Pro motif for metabolic stability. Research characterizes GABAergic, serotonergic and cytokine/interferon-related interactions.
Research Focus
Studied in anxiolytic/neuropsychotropic and immunomodulation (cytokine/interferon) research models.
Lyophilized
-20°C, protected from light and moisture
stable long term.
Reconstituted
2-8°C short term
-20°C for longer aliquots.
Hydrophilic and water-soluble; avoid freeze-thaw; protect from light.
Reviews
Kolomin T, et al. (2018). Protein Pept Lett — Review of molecular mechanisms and GABAergic interaction
Clinical
Panikratova YaR, et al. (2020). Doklady Biological Sciences — Resting-state functional-connectivity study of Selank and Semax
Uchakina ON, et al. (2008). Zh Nevrol Psikhiatr — Th1/Th2 cytokine-balance study in anxiety-asthenic disorders
Zozulia AA, et al. (2008). Zh Nevrol Psikhiatr — Controlled trial in generalized anxiety disorder and neurasthenia
Primary research
Volkova A, et al. (2016). Front Pharmacol — Gene-expression analysis of GABAergic neurotransmission genes in rat frontal cortex
Kost NV, et al. (2001). Bull Exp Biol Med — In vitro study of enkephalin-degrading-enzyme inhibition (human serum)
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
